2021
Systematic review and meta-analysis of outcomes in patients with suspected pulmonary embolism
Patel P, Patel P, Bhatt M, Braun C, Begum H, Nieuwlaat R, Khatib R, Martins C, Zhang Y, Etxeandia-Ikobaltzeta I, Varghese J, Alturkmani H, Bahaj W, Baig M, Kehar R, Mustafa A, Ponnapureddy R, Sethi A, Thomas M, Wooldridge D, Lim W, Bates S, Lang E, Le Gal G, Haramati L, Kline J, Righini M, Wiercioch W, Schünemann H, Mustafa R. Systematic review and meta-analysis of outcomes in patients with suspected pulmonary embolism. Blood Advances 2021, 5: 2237-2244. PMID: 33900385, PMCID: PMC8095140, DOI: 10.1182/bloodadvances.2020002398.Peer-Reviewed Original ResearchConceptsIncidence of VTENegative D-dimerPulmonary embolismVenous thromboembolismPretest probabilityMajor bleedingD-dimerNegative computed tomography scanRecurrent venous thromboembolismCochrane Central RegisterRecurrent pulmonary embolismLow pretest probabilityIntermediate pretest probabilityRelevant conference proceedingsComputed tomography scanHigh pretest probabilityPostthrombotic sequelaeCause mortalityCentral RegisterControlled TrialsIntracranial hemorrhagePrompt evaluationDiagnostic pathwayEligible studiesTomography scan
2009
Potential Impact of Adjusting the Threshold of the Quantitative D‐dimer Based on Pretest Probability of Acute Pulmonary Embolism
Kabrhel C, Courtney D, Camargo CA, Moore CL, Richman PB, Plewa MC, Nordenholtz KE, Smithline HA, Beam DM, Brown MD, Kline JA. Potential Impact of Adjusting the Threshold of the Quantitative D‐dimer Based on Pretest Probability of Acute Pulmonary Embolism. Academic Emergency Medicine 2009, 16: 325-332. PMID: 19298619, DOI: 10.1111/j.1553-2712.2009.00368.x.Peer-Reviewed Original ResearchConceptsNegative predictive valuePulmonary embolismD-dimer testingQuantitative D-dimerPretest probabilityD-dimerVenous thromboembolismQuantitative D-dimer testingPossible pulmonary embolismAcute pulmonary embolismObservational multicenter studyMajority of patientsEmergency department patientsIntermediate pretest probabilityEmergency medicine cliniciansD-dimer cutoffHigh pretest probabilityDifferent D-dimer assaysD-dimer assayEligible patientsDepartment patientsMulticenter studyMedicine cliniciansUnstructured estimatePatients
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