Deregulation of microRNAs by HIV-1 Vpr Protein Leads to the Development of Neurocognitive Disorders*
Mukerjee R, Chang J, Del Valle L, Bagashev A, Gayed M, Lyde R, Hawkins B, Brailoiu E, Cohen E, Power C, Azizi S, Gelman B, Sawaya B. Deregulation of microRNAs by HIV-1 Vpr Protein Leads to the Development of Neurocognitive Disorders*. Journal Of Biological Chemistry 2011, 286: 34976-34985. PMID: 21816823, PMCID: PMC3186354, DOI: 10.1074/jbc.m111.241547.Peer-Reviewed Original ResearchConceptsVpr proteinHIV-1HIV-1-infected target cellsNeuronal dysfunctionHIV-1 Vpr proteinHIV-infected patientsInfection of neuronsEndoplasmic reticulum calcium releaseNeurocognitive disordersDeregulation of calcium homeostasisViral protein ROxidative stress pathwaysGene array assayHuman neuronal cell lineNeuronal cell lineDevelopment of neurocognitive disordersProtein RTarget cellsCalcium homeostasisSynaptic retractionInflammatory proteinsArray assayCell linesHuman neuronsDysfunction
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