2025
TNFR1-mediated senescence and lack of TNFR2-signaling limit human intervertebral disc cell repair potential in degenerative conditions
Gansau J, Grossi E, Rodriguez L, Wang M, Laudier D, Chaudhary S, Hecht A, Fu W, Sebra R, Liu C, Iatridis J. TNFR1-mediated senescence and lack of TNFR2-signaling limit human intervertebral disc cell repair potential in degenerative conditions. Osteoarthritis And Cartilage 2025, 33: 874-887. PMID: 40139648, PMCID: PMC12146073, DOI: 10.1016/j.joca.2025.02.791.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnnulus FibrosusCells, CulturedCellular SenescenceCulture Media, ConditionedFemaleHumansIntervertebral DiscIntervertebral Disc DegenerationMaleMiddle AgedReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IISignal TransductionTumor Necrosis Factor-alphaConceptsTNFR2 signalingConditioned mediumInflammatory responseIVD cellsHuman annulus fibrosusDelivery of macrophagesPainful intervertebral discIntervertebral discAttenuated inflammatory responsePro-inflammatory responseNO effectHuman IVD cellsHuman annulus fibrosus cellsReduced metabolic rateReceptor 2Cytokine mixtureMacrophage populationsHAFS cellsInflammatory proteinsMetabolic impairmentBulk RNA-seqIntervertebral disc repairMetabolic rateCell cycle stateAutopsy subjects
2011
Axial creep loading and unloaded recovery of the human intervertebral disc and the effect of degeneration
O’Connell G, Jacobs NT, Sen S, Vresilovic EJ, Elliott DM. Axial creep loading and unloaded recovery of the human intervertebral disc and the effect of degeneration. Journal Of The Mechanical Behavior Of Biomedical Materials 2011, 4: 933-942. PMID: 21783103, PMCID: PMC3143379, DOI: 10.1016/j.jmbbm.2011.02.002.Peer-Reviewed Original Research
2008
Effect of Degeneration on the Dynamic Viscoelastic Properties of Human Annulus Fibrosus in Tension
Sen S, Boxberger J, Schroeder Y, Orias A, Elliott D. Effect of Degeneration on the Dynamic Viscoelastic Properties of Human Annulus Fibrosus in Tension. 2008, 609-610. DOI: 10.1115/sbc2008-193057.Peer-Reviewed Original ResearchDisc degenerationViscoelastic propertiesStructural finite element modelIntervertebral disc degenerationFinite element modelUniaxial tensile testsPhysiological cyclic loadingQuasi-static conditionsHuman AF tissueDynamic viscoelastic propertiesStatic viscoelastic propertiesAF tissueCyclic loadingElement modelTensile testsIntervertebral discMechanical assessmentRegenerative approachesTissueDegenerate tissueMechanical functionDegenerationAn In Vivo Model of Reduced Nucleus Pulposus Glycosaminoglycan Content in the Rat Lumbar Intervertebral Disc
Boxberger JI, Auerbach JD, Sen S, Elliott DM. An In Vivo Model of Reduced Nucleus Pulposus Glycosaminoglycan Content in the Rat Lumbar Intervertebral Disc. Spine 2008, 33: 146-154. PMID: 18197098, PMCID: PMC2696404, DOI: 10.1097/brs.0b013e31816054f8.Peer-Reviewed Original ResearchConceptsRange of motionVivo modelDisc degenerationEarly stage disc degenerationRat lumbar intervertebral discsRat lumbar spineDevelopment of therapiesIntervertebral disc degenerationLumbar intervertebral discsHistology 4Glycosaminoglycan contentDisease progressionBACKGROUND DATALumbar spineAnimal modelsAltered biochemistryEarly interventionGlycosaminoglycan levelsGlycosaminoglycan lossPhysiologic levelsDegenerationControl levelsIntervertebral discNucleus pulposusWeeks
1984
Acute Prolapsed Lumbar Intervertebral Disc An Epidemiologic Study with Special Reference to Driving Automobiles and Cigarette Smoking
KELSEY J, GITHENS P, O'CONNER T, WEIL U, CALOGERO J, HOLFORD T, WHITE A, WALTER S, OSTFELD A, SOUTHWICK W. Acute Prolapsed Lumbar Intervertebral Disc An Epidemiologic Study with Special Reference to Driving Automobiles and Cigarette Smoking. Spine 1984, 9: 608-613. PMID: 6495031, DOI: 10.1097/00007632-198409000-00012.Peer-Reviewed Original ResearchConceptsCigarette smokingAverage riskNumber of pregnanciesPossible etiologic significanceCase-control studyEpidemiologic case-control studyRatio of menLumbar intervertebral discsNonoccupational factorsFemale ratioRisk factorsEpidemiologic studiesHigh riskSurgical casesEtiologic significanceNumber of childrenLumbar discIntervertebral discHigh heelsSmokingRiskNumber of hoursPast yearPregnancySurgeryAn epidemiological study of acute prolapsed cervical intervertebral disc.
Kelsey J, Githens P, Walter S, Southwick W, Weil U, Holford T, Ostfeld A, Calogero J, O'Connor T, White A. An epidemiological study of acute prolapsed cervical intervertebral disc. Journal Of Bone And Joint Surgery 1984, 66: 907-14. PMID: 6736091, DOI: 10.2106/00004623-198466060-00011.Peer-Reviewed Original ResearchConceptsCervical intervertebral discsCervical discEpidemiological studiesOnset of symptomsNumber of pregnanciesIntervertebral discBorderline statistical significanceSmoking cigarsLive birthsFrequent liftingFourth decadeAge groupsStatistical significanceHigh heelsCertain sportsPositive associationFrequent divingPregnancySymptomsNeckDiagnosisWomenAn epidemiologic study of lifting and twisting on the job and risk for acute prolapsed lumbar intervertebral disc
Kelsey J, Githens P, White A, Holford T, Walter S, O'Connor T, Ostfeld A, Weil U, Southwick W, Calogero J. An epidemiologic study of lifting and twisting on the job and risk for acute prolapsed lumbar intervertebral disc. Journal Of Orthopaedic Research® 1984, 2: 61-66. PMID: 6491800, DOI: 10.1002/jor.1100020110.Peer-Reviewed Original Research
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