2025
TNFR1-mediated senescence and lack of TNFR2-signaling limit human intervertebral disc cell repair potential in degenerative conditions
Gansau J, Grossi E, Rodriguez L, Wang M, Laudier D, Chaudhary S, Hecht A, Fu W, Sebra R, Liu C, Iatridis J. TNFR1-mediated senescence and lack of TNFR2-signaling limit human intervertebral disc cell repair potential in degenerative conditions. Osteoarthritis And Cartilage 2025, 33: 874-887. PMID: 40139648, PMCID: PMC12146073, DOI: 10.1016/j.joca.2025.02.791.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnnulus FibrosusCells, CulturedCellular SenescenceCulture Media, ConditionedFemaleHumansIntervertebral DiscIntervertebral Disc DegenerationMaleMiddle AgedReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IISignal TransductionTumor Necrosis Factor-alphaConceptsTNFR2 signalingConditioned mediumInflammatory responseIVD cellsHuman annulus fibrosusDelivery of macrophagesPainful intervertebral discIntervertebral discAttenuated inflammatory responsePro-inflammatory responseNO effectHuman IVD cellsHuman annulus fibrosus cellsReduced metabolic rateReceptor 2Cytokine mixtureMacrophage populationsHAFS cellsInflammatory proteinsMetabolic impairmentBulk RNA-seqIntervertebral disc repairMetabolic rateCell cycle stateAutopsy subjects
2012
Human annulus fibrosus dynamic tensile modulus increases with degeneration
Sen S, Jacobs NT, Boxberger JI, Elliott DM. Human annulus fibrosus dynamic tensile modulus increases with degeneration. Mechanics Of Materials 2012, 44: 93-98. PMID: 22247579, PMCID: PMC3254102, DOI: 10.1016/j.mechmat.2011.07.016.Peer-Reviewed Original ResearchDynamic viscoelastic propertiesViscoelastic propertiesDynamic modulusStrain levelsCyclic loading conditionsCyclic tensile loadingLinear viscoelastic modelHigher dynamic modulusTensile modulus increasesPhase angleHuman annulus fibrosusTensile samplesTensile loadingDecreased phase angleLoading conditionsEffect of degenerationUniaxial tensionAnnulus fibrosusViscoelastic modelEquilibrium strainModulus increases
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