2024
306 Endothelial Infiltrating Regulatory B Cells and NK T Cells Precipitate Inflammatory Cascade That Leads to Aneurysmal Rupture
Antonios J, Barak T, Gultekin B, Yalcin K, Adenu-Mensah N, Sujijantarat N, Koo A, Haynes J, Hebert R, Matouk C, Gunel M. 306 Endothelial Infiltrating Regulatory B Cells and NK T Cells Precipitate Inflammatory Cascade That Leads to Aneurysmal Rupture. Neurosurgery 2024, 70: 88-89. DOI: 10.1227/neu.0000000000002809_306.Peer-Reviewed Original ResearchRegulatory B cellsB cellsSentinel hemorrhageNK cellsInflammatory cascadeCytotoxic CD8 T cellsRecruitment of NK cellsCD8 T cellsAdjunctive immune therapyEndovascular coil embolizationCoordinated immune responseIntracranial aneurysm developmentImmune therapyRecurrent aneurysmsAneurysmal vessel wallT cellsCoil embolizationRuptured aneurysmsTime of ruptureAneurysm ruptureUnruptured aneurysmsInfiltrating populationPatient populationImmune responseAneurysm development
2022
Vascular aneurysms in Ehlers‐Danlos syndrome subtypes: A systematic review
Shabani M, Abdollahi A, Brar B, MacCarrick G, Venkatesh B, Lima J, Bodurtha J. Vascular aneurysms in Ehlers‐Danlos syndrome subtypes: A systematic review. Clinical Genetics 2022, 103: 261-267. PMID: 36210598, PMCID: PMC12172680, DOI: 10.1111/cge.14245.Peer-Reviewed Original ResearchConceptsEhlers-Danlos syndromeEhlers-Danlos syndrome subtypesRuptured aneurysmsMultiple aneurysmsSubtype of Ehlers-Danlos syndromeVenous systemAneurysm formationHead and neckPresentation of Ehlers-Danlos syndromeLocation of aneurysmsSystematic reviewAbdominopelvic regionInitial presentationCardiac septumAbdominopelvic areaClinical criteriaIntracranial regionAneurysmal lesionsVascular aneurysmsGenetic diagnosisSyndrome subtypesAneurysm developmentEhlers-DanlosAneurysmPatients
2020
Smooth Muscle Cell Reprogramming in Aortic Aneurysms
Chen PY, Qin L, Li G, Malagon-Lopez J, Wang Z, Bergaya S, Gujja S, Caulk AW, Murtada SI, Zhang X, Zhuang ZW, Rao DA, Wang G, Tobiasova Z, Jiang B, Montgomery RR, Sun L, Sun H, Fisher EA, Gulcher JR, Fernandez-Hernando C, Humphrey JD, Tellides G, Chittenden TW, Simons M. Smooth Muscle Cell Reprogramming in Aortic Aneurysms. Cell Stem Cell 2020, 26: 542-557.e11. PMID: 32243809, PMCID: PMC7182079, DOI: 10.1016/j.stem.2020.02.013.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsAortic aneurysmAneurysm developmentMedial smooth muscle cellsAortic aneurysm developmentContractile smooth muscle cellsGrowth factor βHypercholesterolemic dietSmooth muscleAortic wallMesenchymal stem cellsMuscle cellsAneurysmsMarked increaseFactor βExuberant growthStem cellsHuman diseasesCell massCellsAtherosclerosisHypercholesterolemiaInflammationAortaApoE
2019
Simple renal cysts and bovine aortic arch: markers for aortic disease
Brownstein AJ, Bin Mahmood SU, Saeyeldin A, Velasquez Mejia C, Zafar MA, Li Y, Rizzo JA, Dahl NK, Erben Y, Ziganshin BA, Elefteriades JA. Simple renal cysts and bovine aortic arch: markers for aortic disease. Open Heart 2019, 6: e000862. PMID: 30774963, PMCID: PMC6350752, DOI: 10.1136/openhrt-2018-000862.Peer-Reviewed Original ResearchBovine aortic archSimple renal cystsThoracic aortic diseaseAbdominal aortic aneurysmType B aortic dissectionB aortic dissectionAortic dissectionAortic aneurysmAortic diseaseAortic archRenal cystsChronic kidney diseasePresence of hypertensionAortic aneurysm developmentAbdominal CTMultivariable analysisKidney diseaseRetrospective searchPatientsAneurysm developmentAneurysmsPropensity scoreDiseaseDissectionPrevalence
2017
Preclinical Evaluation of RYM1, a Matrix Metalloproteinase–Targeted Tracer for Imaging Aneurysm
Toczek J, Ye Y, Gona K, Kim HY, Han J, Razavian M, Golestani R, Zhang J, Wu TL, Jung JJ, Sadeghi MM. Preclinical Evaluation of RYM1, a Matrix Metalloproteinase–Targeted Tracer for Imaging Aneurysm. Journal Of Nuclear Medicine 2017, 58: 1318-1323. PMID: 28360209, PMCID: PMC5537616, DOI: 10.2967/jnumed.116.188656.Peer-Reviewed Original ResearchConceptsMatrix metalloproteinasesMMP activityCD68 expressionCarotid aneurysmsPreclinical evaluationAneurysm developmentAbdominal aortic aneurysm (AAA) developmentAortic MMP activityEarly vascular imagingAngiotensin II infusionLow blood levelsAortic aneurysm developmentSPECT/CT imagesReverse transcription-polymerase chain reactionSPECT/CT imagingRapid blood clearanceSmall-animal SPECT/CT imagingII infusionAortic uptakeAngiotensin IIBlood levelsPolymerase chain reactionAAA formationDeficient miceApolipoprotein E
2012
Carotid Intima-Media Thickness Provides Evidence that Ascending Aortic Aneurysm Protects against Systemic Atherosclerosis
Hung A, Zafar M, Mukherjee S, Tranquilli M, Scoutt LM, Elefteriades JA. Carotid Intima-Media Thickness Provides Evidence that Ascending Aortic Aneurysm Protects against Systemic Atherosclerosis. Cardiology 2012, 123: 71-77. PMID: 23006774, DOI: 10.1159/000341234.Peer-Reviewed Original ResearchConceptsIntima-media thicknessCarotid intima-media thicknessAortic aneurysmCalcium scoreAortic calcium scoreAverage intima-media thicknessAortic aneurysm patientsCarotid IMT valuesDegree of atherosclerosisPositive family historyAortic aneurysm developmentDevelopment of atherosclerosisCommon carotid arterySystemic atherosclerosisAneurysm patientsIMT valuesMale genderRisk factorsCarotid arteryFamily historyMultiple linear regression analysisAtherosclerosisEarly markerAneurysm developmentAneurysms
1988
Age of onset, pattern of distribution, and histology of aneurysm development in a genetically predisposed mouse model
Brophy C, Tilson J, Braverman I, Tilson M. Age of onset, pattern of distribution, and histology of aneurysm development in a genetically predisposed mouse model. Journal Of Vascular Surgery 1988, 8: 45-48. PMID: 3385878, DOI: 10.1016/0741-5214(88)90242-x.Peer-Reviewed Original ResearchConceptsAge of onsetAneurysm developmentBlotchy miceIncidence of aneurysmsMonths of ageSmooth muscle cellsPossible therapeutic interventionsAneurysmal dilatationAneurysmal diseaseHistologic featuresMost aneurysmsMice 1Multiple aneurysmsAortic aneurysmAneurysmal developmentHistologic changesHistologic samplingGross evidenceMouse modelPattern of distributionLeft ventricleMouse aortaNormal animalsTherapeutic interventionsAneurysms
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