2017
Preclinical Evaluation of RYM1, a Matrix Metalloproteinase–Targeted Tracer for Imaging Aneurysm
Toczek J, Ye Y, Gona K, Kim HY, Han J, Razavian M, Golestani R, Zhang J, Wu TL, Jung JJ, Sadeghi MM. Preclinical Evaluation of RYM1, a Matrix Metalloproteinase–Targeted Tracer for Imaging Aneurysm. Journal Of Nuclear Medicine 2017, 58: 1318-1323. PMID: 28360209, PMCID: PMC5537616, DOI: 10.2967/jnumed.116.188656.Peer-Reviewed Original ResearchConceptsMatrix metalloproteinasesMMP activityCD68 expressionCarotid aneurysmsPreclinical evaluationAneurysm developmentAbdominal aortic aneurysm (AAA) developmentAortic MMP activityEarly vascular imagingAngiotensin II infusionLow blood levelsAortic aneurysm developmentSPECT/CT imagesReverse transcription-polymerase chain reactionSPECT/CT imagingRapid blood clearanceSmall-animal SPECT/CT imagingII infusionAortic uptakeAngiotensin IIBlood levelsPolymerase chain reactionAAA formationDeficient miceApolipoprotein E
2014
Safety of reduced dose of mycophenolate mofetil combined with tacrolimus in living-donor liver transplantation
Kim H, Yi N, Lee J, Kim J, Moon M, Jeong J, Lee J, You T, Suh S, Park M, Choi Y, Hong G, Lee H, Lee K, Suh K. Safety of reduced dose of mycophenolate mofetil combined with tacrolimus in living-donor liver transplantation. Clinical And Molecular Hepatology 2014, 20: 291-299. PMID: 25320733, PMCID: PMC4197178, DOI: 10.3350/cmh.2014.20.3.291.Peer-Reviewed Original ResearchConceptsDose of mycophenolate mofetilReduced dose of mycophenolate mofetilLiving-donor liver transplantationMycophenolate mofetilReduced doseSide effectsProtocol biopsiesPost-LDLTLiver transplantationLower doses of mycophenolate mofetilLow levels of tacrolimusAdult living-donor liver transplantationRejection-free survival ratesExcellent short-term outcomesLevels of tacrolimusProspective pharmacokinetic studyRecommended therapeutic rangePostoperative day 7Area under the curveAssociated with lower blood levelsShort-term outcomesYears post-LDLTMonths post-LDLTLow blood levelsAUC(0-12
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