2015
MHC Class II Presentation Is Controlled by the Lysosomal Small GTPase, Arl8b
Michelet X, Garg S, Wolf B, Tuli A, Ricciardi-Castagnoli P, Brenner M. MHC Class II Presentation Is Controlled by the Lysosomal Small GTPase, Arl8b. The Journal Of Immunology 2015, 194: 2079-2088. PMID: 25637027, DOI: 10.4049/jimmunol.1401072.Peer-Reviewed Original ResearchMeSH KeywordsADP-Ribosylation FactorsAnimalsAntigen PresentationAntigensBone Marrow CellsCD4-Positive T-LymphocytesCell LineChickensDendritic CellsEndosomesGene Expression RegulationHistocompatibility Antigens Class IILysosomesMiceMice, Inbred C57BLOvalbuminPrimary Cell CultureProtein TransportRNA, Small InterferingSignal TransductionSpleenConceptsDendritic cellsMHC-II presentationMHC II-peptide complexesII presentationII-peptide complexesT cellsCell surfaceCD4(+) T cellsPrime naive T cellsAg-presenting moleculesMHC class II presentationNaive T cellsMHC class IIT cell recognitionMHC II compartmentsGTPase Rab5Small GTPasesClass II presentationMHC II moleculesEndocytic vesiclesComplex formationArl8bAg deliveryRegulate formationExogenous Ag
2002
Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane
Chow A, Toomre D, Garrett W, Mellman I. Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane. Nature 2002, 418: 988-994. PMID: 12198549, DOI: 10.1038/nature01006.Peer-Reviewed Original ResearchConceptsDendritic cellsMajor histocompatibility complex (MHC) class II moleculesLive dendritic cellsImmature dendritic cellsCo-stimulatory moleculesMHC II moleculesClass II moleculesInternalized antigensInflammatory mediatorsII-peptide complexesMHC-IIT lymphocytesImmune responseMHC class II transportPeptide antigensMaturation triggerClass II transportAntigenGreen fluorescent proteinCellsLysosomal compartmentPlasma membraneLysosomesTerminal degradative compartmentMicrobial products
1994
In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides
Avva R, Cresswell P. In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides. Immunity 1994, 1: 763-774. PMID: 7895165, DOI: 10.1016/s1074-7613(94)80018-9.Peer-Reviewed Original ResearchConceptsHLA-DM expressionDR alpha beta dimersHLA-DR moleculesCLIP dissociationClass II moleculesHLA-DR complexInvariant chain peptideII-peptide complexesPrimary aliphatic aminesResidual fragmentsChain-derived peptideClass IIHLA-DMAliphatic aminesCarboxylic acidsSuch complexesUnbranched hydrocarbonsAlpha beta dimersChain peptideInvariant chain-derived peptidesComplexesVivoCLIP complexBeta dimersDissociation
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