2024
Cutting Edge: Phagosome-associated Autophagosomes Containing Antigens and Proteasomes Drive TAP-Independent Cross-Presentation.
Sengupta D, Galicia-Pereyra R, Han P, Graham M, Liu X, Arshad N, Cresswell P. Cutting Edge: Phagosome-associated Autophagosomes Containing Antigens and Proteasomes Drive TAP-Independent Cross-Presentation. The Journal Of Immunology 2024, 212: 1063-1068. PMID: 38353614, PMCID: PMC10948299, DOI: 10.4049/jimmunol.2200446.Peer-Reviewed Original ResearchCross-PresentationTransporter associated with Ag processingExogenous AgCD8-positive T lymphocytesAntigenic peptidesMHC-I moleculesDendritic cellsProteasomal deliveryT lymphocytesCytosolic proteasomeActive proteasomesEndocytic compartmentsTAP-independentLumen of phagosomesSubcellular compartmentsEndoplasmic reticulumEndolysosomal vesiclesMHC-IAg processingBind to MHC-IProteasome
2015
MHC Class II Presentation Is Controlled by the Lysosomal Small GTPase, Arl8b
Michelet X, Garg S, Wolf B, Tuli A, Ricciardi-Castagnoli P, Brenner M. MHC Class II Presentation Is Controlled by the Lysosomal Small GTPase, Arl8b. The Journal Of Immunology 2015, 194: 2079-2088. PMID: 25637027, DOI: 10.4049/jimmunol.1401072.Peer-Reviewed Original ResearchMeSH KeywordsADP-Ribosylation FactorsAnimalsAntigen PresentationAntigensBone Marrow CellsCD4-Positive T-LymphocytesCell LineChickensDendritic CellsEndosomesGene Expression RegulationHistocompatibility Antigens Class IILysosomesMiceMice, Inbred C57BLOvalbuminPrimary Cell CultureProtein TransportRNA, Small InterferingSignal TransductionSpleenConceptsDendritic cellsMHC-II presentationMHC II-peptide complexesII presentationII-peptide complexesT cellsCell surfaceCD4(+) T cellsPrime naive T cellsAg-presenting moleculesMHC class II presentationNaive T cellsMHC class IIT cell recognitionMHC II compartmentsGTPase Rab5Small GTPasesClass II presentationMHC II moleculesEndocytic vesiclesComplex formationArl8bAg deliveryRegulate formationExogenous Ag
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