2025
Unveiling the shared etiology between gastrointestinal disorders and valvular heart diseases through a genome-wide pleiotropy study
Xu J, Liu Z, Wu L, Pei F, Jiang H, Cheng C, Yang W, Yuan J, Polimanti R, Yang Y. Unveiling the shared etiology between gastrointestinal disorders and valvular heart diseases through a genome-wide pleiotropy study. Npj Cardiovascular Health 2025, 2: 17. DOI: 10.1038/s44325-025-00054-w.Peer-Reviewed Original ResearchLinkage disequilibrium score regressionGenetic correlationsPleiotropic analysisPleiotropy analysisGut microbiotaGenetic pathwaysMicrobial influenceScore regressionPleiotropic effectsGenetic linkPathwayHeart diseaseButyricicoccusMicrobiotaGenesGutComposite null hypothesisVariantsGastrointestinal disordersCausal effectsLinkageDiseaseIBD
2022
Simplified Machine Learning Models Can Accurately Identify High-Need High-Cost Patients With Inflammatory Bowel Disease
Nguyen N, Patel S, Gabunilas J, Qian A, Cecil A, Jairath V, Sandborn W, Ohno-Machado L, Chen P, Singh S. Simplified Machine Learning Models Can Accurately Identify High-Need High-Cost Patients With Inflammatory Bowel Disease. Clinical And Translational Gastroenterology 2022, 13: e00507. PMID: 35905414, PMCID: PMC10476830, DOI: 10.14309/ctg.0000000000000507.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseUnplanned healthcare utilizationAdult patientsBowel diseaseHealthcare utilizationHealthcare costsLogistic regressionRetrospective cohort studyNationwide Readmissions DatabaseIdentification of patientsAdministrative claims dataHigh-cost patientsHNHC patientsCohort studyHospitalized patientsClaims dataHigh riskPatientsTraditional logistic regressionDerivation dataMean AUCIBDMean areaCharacteristic curveDiseaseTu1436: SYSTEMIC CORTICOSTEROIDS BUT NOT ANTI-TNF ARE ASSOCIATED WITH INCREASED RISK OF HOSPITALIZATION, INTENSIVE CARE, AND DEATH AMONG PATIENTS WITH IBD: RESULTS FROM A LARGE, POPULATION-BASED COHORT
Kappelman M, Parlett L, Haynes K, Selvan M, Ma Q, Nair V, Adimadhyam S, Hou L, Wolfe A, Toh D, Burris J, Dorand J, Lewis J, Long M. Tu1436: SYSTEMIC CORTICOSTEROIDS BUT NOT ANTI-TNF ARE ASSOCIATED WITH INCREASED RISK OF HOSPITALIZATION, INTENSIVE CARE, AND DEATH AMONG PATIENTS WITH IBD: RESULTS FROM A LARGE, POPULATION-BASED COHORT. Gastroenterology 2022, 162: s-959. DOI: 10.1016/s0016-5085(22)62274-1.Peer-Reviewed Original ResearchSu1018: UNPLANNED HEALTHCARE UTILIZATION AND SAFETY OF BIOLOGIC THERAPY IN HISPANIC VS. NON-HISPANIC PATIENTS WITH IBD
Nguyen N, Luo J, Paul P, Kim J, Syal G, Ha C, Rudrapatna V, Park S, Parekh N, Zheng K, Sauk J, Limketkai B, Fleshner P, Eisenstein S, Ramamoorthy S, Melmed G, Boland B, Mahadevan U, Sandborn W, Ohno-Machado L, Mcgovern D, Singh S. Su1018: UNPLANNED HEALTHCARE UTILIZATION AND SAFETY OF BIOLOGIC THERAPY IN HISPANIC VS. NON-HISPANIC PATIENTS WITH IBD. Gastroenterology 2022, 162: s-482-s-483. DOI: 10.1016/s0016-5085(22)61145-4.Peer-Reviewed Original Research
2020
Sulfamethoxazole drug stress upregulates antioxidant immunomodulatory metabolites in Escherichia coli
Park HB, Wei Z, Oh J, Xu H, Kim CS, Wang R, Wyche TP, Piizzi G, Flavell RA, Crawford JM. Sulfamethoxazole drug stress upregulates antioxidant immunomodulatory metabolites in Escherichia coli. Nature Microbiology 2020, 5: 1319-1329. PMID: 32719505, PMCID: PMC7581551, DOI: 10.1038/s41564-020-0763-4.Peer-Reviewed Original ResearchConceptsAnti-inflammatory interleukin-10Colitis mouse modelInflammatory bowel diseaseColitis symptomsBowel diseaseInterleukin-10Immunological markersPathogenic roleImmunomodulatory metabolitesImmunomodulatory phenotypeGastrointestinal tractMouse modelImmunological activityPrimary human tissuesDrug stressSubinhibitory levelsHuman tissuesEnvironmental isolatesCertain strainsMetabolic pathwaysMetabolitesPatientsEscherichia coliSymptomsIBDIntelectin-1 Affects Interleukin-13-Induced Mucociliary Airway Dysfunction and Its Expression Is Regulated by a Cis-eQTL Associated with Development of Asthma and IBD
Everman J, Jackson N, Sajuthi S, Saef B, Chioccioli M, Dyjack N, Powell R, Rios C, Montgomery M, Oh S, Eng C, Elhawary J, Feriani L, Armstrong M, Gomez J, Zhang X, Medina V, Chu H, Cicuta P, Rodriguez-Santana J, Reisdorph N, Burchard E, Seibold M. Intelectin-1 Affects Interleukin-13-Induced Mucociliary Airway Dysfunction and Its Expression Is Regulated by a Cis-eQTL Associated with Development of Asthma and IBD. 2020, a7400-a7400. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7400.Peer-Reviewed Original Research
2019
Distinct Cutoff Values of Adalimumab Trough Levels Are Associated With Different Therapeutic Outcomes in Patients With Inflammatory Bowel Disease
Park S, Al-Bawardy B, Aniwan S, Kane S, Coelho-Prabhu N, Papadakis K, Kisiel J, Bruining D, Faubion W, Raffals L, Pardi D, Tremaine W, Stephens M, Tung J, Khanna S, Willrich M, Loftus E. Distinct Cutoff Values of Adalimumab Trough Levels Are Associated With Different Therapeutic Outcomes in Patients With Inflammatory Bowel Disease. Crohn's & Colitis 360 2019, 1: otz047. DOI: 10.1093/crocol/otz047.Peer-Reviewed Original ResearchAdalimumab trough levelsRadiologic responseDisease activityTrough levelsReferral center-based cohortInflammatory bowel disease patientsRadiologic disease activityBowel disease patientsInflammatory bowel diseaseC-reactive proteinDifferent therapeutic outcomesHigher cutoff levelsBowel diseaseDisease patientsCutoff levelTherapeutic outcomesCutoff valuePatientsCohortIBDLevelsDiseaseResponseMo1862 – No Increaed Rates of Adverse Ibd-Related Outcomes for Patients with IBD and Concomitant Prostate Cancer Treated with Radiation Therapy
Feagins L, Kim J, Chandrakumaran A, Gandle C, Naik K, Hou J, Yao M, Gaidos J. Mo1862 – No Increaed Rates of Adverse Ibd-Related Outcomes for Patients with IBD and Concomitant Prostate Cancer Treated with Radiation Therapy. Gastroenterology 2019, 156: s-867. DOI: 10.1016/s0016-5085(19)39129-2.Peer-Reviewed Original ResearchP071 NO INCREASED RATE OF ADVERSE IBD-RELATED OUTCOMES FOR PATIENTS WITH IBD AND CONCURRENT PROSTATE CANCER TREATED WITH RADIATION THERAPY
Feagins L, Kim J, Chandrakumaran A, Gandle C, Naik K, Hou J, Yao M, Gaidos J. P071 NO INCREASED RATE OF ADVERSE IBD-RELATED OUTCOMES FOR PATIENTS WITH IBD AND CONCURRENT PROSTATE CANCER TREATED WITH RADIATION THERAPY. Inflammatory Bowel Diseases 2019, 25: s34-s34. DOI: 10.1093/ibd/izy393.078.Peer-Reviewed Original ResearchP071 NO INCREASED RATE OF ADVERSE IBD-RELATED OUTCOMES FOR PATIENTS WITH IBD AND CONCURRENT PROSTATE CANCER TREATED WITH RADIATION THERAPY
Feagins L, Kim J, Chandrakumaran A, Gandle C, Naik K, Hou J, Yao M, Gaidos J. P071 NO INCREASED RATE OF ADVERSE IBD-RELATED OUTCOMES FOR PATIENTS WITH IBD AND CONCURRENT PROSTATE CANCER TREATED WITH RADIATION THERAPY. Gastroenterology 2019, 156: s49-s50. DOI: 10.1053/j.gastro.2019.01.130.Peer-Reviewed Original Research
2008
Epigenetic Regulation of WNT Signaling Pathway Genes in Inflammatory Bowel Disease (IBD) Associated Neoplasia
Dhir M, Montgomery EA, Glöckner SC, Schuebel KE, Hooker CM, Herman JG, Baylin SB, Gearhart SL, Ahuja N. Epigenetic Regulation of WNT Signaling Pathway Genes in Inflammatory Bowel Disease (IBD) Associated Neoplasia. Journal Of Gastrointestinal Surgery 2008, 12: 1745-1753. PMID: 18716850, PMCID: PMC3976145, DOI: 10.1007/s11605-008-0633-5.Peer-Reviewed Original ResearchConceptsInflammatory Bowel Disease-Associated NeoplasiaIBD colitisNormal colon samplesColorectal cancerLogistic regression modelsAssociated neoplasiaWnt Signaling Pathway GenesMultivariate logistic regression modelPathogenesis of IBDUnivariate logistic regression modelDevelopment of IBDSporadic colorectal cancerProgressive increaseEarly eventsIBD samplesRegression modelsPathway genesCRC samplesColitisNeoplasiaIBDPathway dysregulationColon samplesSignaling Pathway GenesTissue samples
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