2008
HLA Class II Transgenic Mice Mimic Human Inflammatory Diseases
Mangalam A, Rajagopalan G, Taneja V, David C. HLA Class II Transgenic Mice Mimic Human Inflammatory Diseases. Advances In Immunology 2008, 97: 65-147. PMID: 18501769, DOI: 10.1016/s0065-2776(08)00002-3.Peer-Reviewed Original ResearchConceptsHLA class II transgenic miceClass II moleculesII transgenic miceCommon autoimmune diseaseAutoimmune diseasesInflammatory diseasesTransgenic miceClass II genesDQ allelesHLA class II associationsInsulin-dependent diabetes mellitusHLA class II moleculesHLA transgenic miceCD4 T cellsClass II associationsHuman class II moleculesAutoimmune disease developmentToxic shock syndromeT cell repertoireHLA class II genesHuman inflammatory diseasesSimilar antigenic epitopesMHC class II genesAutoimmune myocarditisDiabetes mellitus
2002
HLA Class II Influences the Immune Response and Antibody Diversification to Ro60/Sjögren’s Syndrome-A: Heightened Antibody Responses and Epitope Spreading in Mice Expressing HLA-DR molecules
Paisansinsup T, Deshmukh US, Chowdhary VR, Luthra HS, Fu SM, David CS. HLA Class II Influences the Immune Response and Antibody Diversification to Ro60/Sjögren’s Syndrome-A: Heightened Antibody Responses and Epitope Spreading in Mice Expressing HLA-DR molecules. The Journal Of Immunology 2002, 168: 5876-5884. PMID: 12023392, DOI: 10.4049/jimmunol.168.11.5876.Peer-Reviewed Original ResearchConceptsHLA class II genesImmune responseCell epitopesB-cell epitopesDQ6 miceDQ8 miceSjögren's syndromeClass II genesDominant T cell epitopesMurine class II moleculesSystemic lupus erythematosusHLA class IISera of patientsB cell responsesDominant B-cell epitopesHLA-DR moleculesT cell epitopesClass II moleculesLupus erythematosusAntibody responseDR3 miceCell responsesHigh titersClass IISyndrome
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