2021
Single cell immunophenotyping of the skin lesion erythema migrans Identifies IgM memory B cells
Jiang R, Meng H, Raddassi K, Fleming I, Hoehn KB, Dardick KR, Belperron AA, Montgomery RR, Shalek AK, Hafler DA, Kleinstein SH, Bockenstedt LK. Single cell immunophenotyping of the skin lesion erythema migrans Identifies IgM memory B cells. JCI Insight 2021, 6: e148035. PMID: 34061047, PMCID: PMC8262471, DOI: 10.1172/jci.insight.148035.Peer-Reviewed Original ResearchConceptsMemory B cellsErythema migransB cellsEM lesionsIgM memory B cellsLyme diseaseB-cell receptor sequencingSkin infection siteCell receptor sequencingEarly Lyme diseaseLocal antigen presentationSkin immune responsesB cell populationsSingle-cell immunophenotypingMHC class II genesUninvolved skinImmune cellsSpirochetal infectionAntigen presentationCell immunophenotypingT cellsImmune responseIsotype usageAntibody productionInitial signs
2008
HLA Class II Transgenic Mice Mimic Human Inflammatory Diseases
Mangalam A, Rajagopalan G, Taneja V, David C. HLA Class II Transgenic Mice Mimic Human Inflammatory Diseases. Advances In Immunology 2008, 97: 65-147. PMID: 18501769, DOI: 10.1016/s0065-2776(08)00002-3.Peer-Reviewed Original ResearchConceptsHLA class II transgenic miceClass II moleculesII transgenic miceCommon autoimmune diseaseAutoimmune diseasesInflammatory diseasesTransgenic miceClass II genesDQ allelesHLA class II associationsInsulin-dependent diabetes mellitusHLA class II moleculesHLA transgenic miceCD4 T cellsClass II associationsHuman class II moleculesAutoimmune disease developmentToxic shock syndromeT cell repertoireHLA class II genesHuman inflammatory diseasesSimilar antigenic epitopesMHC class II genesAutoimmune myocarditisDiabetes mellitus
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