2025
Reclassification of pineal tumor as high-grade astrocytoma with piloid features through methylation profiling: illustrative case
Dincer A, Kim M, Hüseyinoglu Z, Chavez M, McGuone D, Moliterno J. Reclassification of pineal tumor as high-grade astrocytoma with piloid features through methylation profiling: illustrative case. Journal Of Neurosurgery Case Lessons 2025, 9: case24778. PMID: 40324324, PMCID: PMC12051993, DOI: 10.3171/case24778.Peer-Reviewed Original ResearchHigh-grade astrocytomasPiloid featuresHigh-grade neuroepithelial tumorCNS tumor classificationGross-total resectionHigh-grade pathologyEndoscopic third ventriculostomyRight-sided weaknessMethylation profilesClinically relevant changesNeuroepithelial tumorsSuboccipital craniectomyTumor sizePineal tumorsPineal regionThird ventriculostomyTumor typesClinical trialsGlioma subtypesBiopsy samplesDNA methylation profilesTumorTargeted therapeuticsHistological appearanceInterval increase
2022
Mildly dysplastic oral lesions with optically-detectable abnormalities share genetic similarities with severely dysplastic lesions
Brenes D, Nipper A, Tan M, Gleber-Netto F, Schwarz R, Pickering C, Williams M, Vigneswaran N, Gillenwater A, Sikora A, Richards-Kortum R. Mildly dysplastic oral lesions with optically-detectable abnormalities share genetic similarities with severely dysplastic lesions. Oral Oncology 2022, 135: 106232. PMID: 36335817, PMCID: PMC9881670, DOI: 10.1016/j.oraloncology.2022.106232.Peer-Reviewed Original ResearchConceptsOral premalignant lesionsMild dysplasiaSevere dysplasiaOral lesionsPremalignant lesionsDysplastic oral lesionsHigh-grade pathologySubset of lesionsLoss of autofluorescenceDysplastic lesionsOptical imaging studiesOral surgeryDysplasiaDetectable abnormalitiesPatient careLesionsImaging studiesEpithelial cell nucleiPatientsGene expressionGene expression profilesMarkersGene expression analysisSimilar gene expressionExpression profilesCorrelation of circulating tumor DNA (ctDNA) with clinical outcomes in appendiceal cancers (AC).
Kothary V, Eng O, Polite B, Liao C, Catenacci D, Dhiman A, Turaga K, Shergill A. Correlation of circulating tumor DNA (ctDNA) with clinical outcomes in appendiceal cancers (AC). Journal Of Clinical Oncology 2022, 40: 29-29. DOI: 10.1200/jco.2022.40.4_suppl.029.Peer-Reviewed Original ResearchAppendiceal cancerCEA levelsDisease courseMedian duration to recurrenceClinical evidence of recurrenceHeterogeneous group of rare tumorsGroup of rare tumorsDuration to recurrenceConventional tumor markersElevated CEA levelsHigh-grade pathologyEvidence of recurrenceResponse to therapyRecurrence risk predictionRare tumorCtDNA testingMedian durationTumor DNAPositive CEATumor markersInitial treatmentClinical outcomesProspective studyInstitutional experienceClinical evidence
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