2007
Endothelial Activation and Neointimal Hyperplasia: A Double-Edged Sword
Khurana R, Simons M. Endothelial Activation and Neointimal Hyperplasia: A Double-Edged Sword. 2007, 75-84. DOI: 10.1007/1-4020-5955-8_4.Peer-Reviewed Original ResearchActivated endothelial cellsAngiogenic growth factorsNeointimal thickeningEndothelial cellsGrowth factorPercutaneous revascularization proceduresVascular smooth muscle cellsNumerous preclinical modelsVasa vasorum neovascularizationEndothelial cell activationVessel wall remodelingSmooth muscle cellsRole of VEGFPotent angiogenic growth factorRevascularization proceduresStent eraEndothelial activationInflammatory cellsNew capillary growthParacrine sourceVascular responsesNeointimal accumulationEndothelial repairEndovascular proceduresPreclinical models
2005
Attenuation of Accumulation of Neointimal Lipid by Pioglitazone in Mice Genetically Deficient in Insulin Receptor Substrate-2 and Apolipoprotein E
Clough M, Schneider D, Sobel B, White M, Wadsworth M, Taatjes D. Attenuation of Accumulation of Neointimal Lipid by Pioglitazone in Mice Genetically Deficient in Insulin Receptor Substrate-2 and Apolipoprotein E. Journal Of Histochemistry & Cytochemistry 2005, 53: 603-610. PMID: 15872053, DOI: 10.1369/jhc.4a6590.2005.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnimalsAortaApolipoproteins EArteriosclerosisHyperlipidemiasHypoglycemic AgentsInsulin Receptor Substrate ProteinsInsulin ResistanceIntracellular Signaling Peptides and ProteinsLipid MetabolismMiceMice, Inbred C57BLMice, KnockoutPhosphoproteinsPioglitazoneReceptor, InsulinThiazolidinedionesTunica IntimaConceptsInsulin resistanceApolipoprotein EAcute coronary syndromeVulnerable atherosclerotic plaquesInsulin receptor substrate 2Accumulation of lipidsCoronary syndromeProximal aortaInsulin sensitizersNeointimal accumulationAtheroma formationAortic intimaAtherosclerotic lesionsAtherosclerotic plaquesType 2PioglitazoneMiceLesionsCross-sectional areaHeterozygous deficiencyAtherogenesisSubstrate 2TreatmentLipidsAtheroma
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