2010
Matrix-Specific Protein Kinase A Signaling Regulates p21-Activated Kinase Activation by Flow in Endothelial Cells
Funk SD, Yurdagul A, Green JM, Jhaveri KA, Schwartz MA, Orr AW. Matrix-Specific Protein Kinase A Signaling Regulates p21-Activated Kinase Activation by Flow in Endothelial Cells. Circulation Research 2010, 106: 1394-1403. PMID: 20224042, PMCID: PMC2862370, DOI: 10.1161/circresaha.109.210286.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Inflammatory AgentsBasement MembraneCattlecdc42 GTP-Binding ProteinCells, CulturedCyclic AMP-Dependent Protein KinasesEndothelial CellsEnzyme ActivationEnzyme ActivatorsHumansIloprostInflammationInflammation MediatorsInjections, IntraperitonealIntegrinsMaleMechanotransduction, CellularMiceMice, Inbred C57BLNF-kappa Bp21-Activated KinasesPhosphorylationProtein Kinase InhibitorsPulsatile Flowrac GTP-Binding ProteinsRegional Blood FlowStress, MechanicalTime FactorsTransfectionConceptsInflammatory gene expressionNF-kappaB activationInflammatory signalingEndothelial cellsProstacyclin analogue iloprostBasement membrane proteinsBlood flow patternsPKA-dependent inhibitionInflammatory pathwaysAnalogue iloprostGene expressionKappaB activationNF-kappaB.Subendothelial extracellular matrixNuclear factorPAK activationBasement membrane
2008
Prostacyclin primes pregnant human myometrium for an enhanced contractile response in parturition
Fetalvero KM, Zhang P, Shyu M, Young BT, Hwa J, Young RC, Martin KA. Prostacyclin primes pregnant human myometrium for an enhanced contractile response in parturition. Journal Of Clinical Investigation 2008, 118: 3966-3979. PMID: 19033666, PMCID: PMC2582928, DOI: 10.1172/jci33800.Peer-Reviewed Original ResearchConceptsEnhanced contractile responseContractile responseMyometrial activationConnexin 43Contractile proteinsStrong phasic contractionsMaximal contractile responseHuman myometrial tissueOnset of laborPGI2 analog iloprostSmooth muscle relaxantPregnant human myometriumGap junction protein connexin 43Preterm laborPhasic contractionsPregnant stateProtein connexin 43Contractile agonistsMuscle relaxantsAnalogue iloprostHuman myometriumPGI2 receptorCOX-2Smooth muscleMyometrial tissue
2006
The prostacyclin receptor induces human vascular smooth muscle cell differentiation via PKA
Fetalvero K, Shyu M, Nomikos A, Chiu Y, Wagner R, Powell R, Hwa J, Martin K. The prostacyclin receptor induces human vascular smooth muscle cell differentiation via PKA. The FASEB Journal 2006, 20: a665-a666. DOI: 10.1096/fasebj.20.4.a665-d.Peer-Reviewed Original ResearchVascular smooth muscle cellsHuman vascular smooth muscle cellsCardiovascular eventsHuman vascular smooth muscle cell differentiationProstacyclin receptorVSMC phenotypeSelective COX-2 inhibitorsAdverse cardiovascular eventsSuperficial femoral arteryProstacyclin analogue iloprostCOX-2 inhibitorsSmooth muscle cellsCAMP/PKA signalingVascular smooth muscle cell differentiationSmooth muscle differentiation markersSmooth muscle cell differentiationArterial injuryCardioprotective effectsFemoral arteryAnalogue iloprostClinical trialsH-caldesmonOrgan donorsAnimal modelsNM iloprost
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