2021
Human-Induced Pluripotent Stem-Cell-Derived Smooth Muscle Cells Increase Angiogenesis to Treat Hindlimb Ischemia
Gao X, Gao M, Gorecka J, Langford J, Liu J, Luo J, Taniguchi R, Matsubara Y, Liu H, Guo L, Gu Y, Qyang Y, Dardik A. Human-Induced Pluripotent Stem-Cell-Derived Smooth Muscle Cells Increase Angiogenesis to Treat Hindlimb Ischemia. Cells 2021, 10: 792. PMID: 33918299, PMCID: PMC8066461, DOI: 10.3390/cells10040792.Peer-Reviewed Original ResearchConceptsLimb-threatening ischemiaSmooth muscle cellsHindlimb ischemiaFunctional outcomeChronic limb-threatening ischemiaMuscle cellsVascular endothelial growth factor (VEGF) expressionM2-type macrophagesMurine hindlimb ischemia modelNumber of macrophagesGrowth factor expressionLaser Doppler imagingStem cell sourceHindlimb ischemia modelStem cellsConsiderable ethical issuesTranslatable therapyIschemic limbsRenewable stem cell sourcesIschemia modelCapillary densityBlood flowIschemiaNovel treatmentsNude mice
2019
Tubular GM-CSF Promotes Late MCP-1/CCR2-Mediated Fibrosis and Inflammation after Ischemia/Reperfusion Injury
Xu L, Sharkey D, Cantley LG. Tubular GM-CSF Promotes Late MCP-1/CCR2-Mediated Fibrosis and Inflammation after Ischemia/Reperfusion Injury. Journal Of The American Society Of Nephrology 2019, 30: 1825-1840. PMID: 31315923, PMCID: PMC6779361, DOI: 10.1681/asn.2019010068.Peer-Reviewed Original ResearchConceptsIschemia/reperfusion injuryWild-type miceTubular cellsTubular injuryReperfusion injuryImmune cellsKidney ischemia/reperfusion injuryUnilateral ischemia/reperfusion injuryMCP-1/CCR2Monocyte chemoattractant protein-1Initial kidney damageInjured tubular cellsKidney 14 daysKidney injury markersProgressive interstitial fibrosisProfibrotic growth factorsChemoattractant protein-1MCP-1 receptorGranulocyte-macrophage colony-stimulating factorRenal tubular cellsNumber of macrophagesTime of repairColony-stimulating factorCoculture of macrophagesMacrophages persist
2018
Adipose-derived mesenchymal stem cells accelerate diabetic wound healing in a similar fashion as bone marrow-derived cells
Guo J, Hu H, Gorecka J, Bai H, He H, Assi R, Isaji T, Wang T, Setia O, Lopes L, Gu Y, Dardik A. Adipose-derived mesenchymal stem cells accelerate diabetic wound healing in a similar fashion as bone marrow-derived cells. American Journal Of Physiology - Cell Physiology 2018, 315: c885-c896. PMID: 30404559, PMCID: PMC6336941, DOI: 10.1152/ajpcell.00120.2018.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAnimalsBone Marrow CellsCell ProliferationCell SurvivalDiabetes Mellitus, ExperimentalGene Expression Regulation, DevelopmentalHumansMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMiceNeovascularization, PhysiologicPlatelet Endothelial Cell Adhesion Molecule-1Vascular Endothelial Growth Factor AWound HealingConceptsBone marrow-derived mesenchymal stem cellsBiomimetic collagen scaffoldStem cellsDiabetic wound healingMesenchymal stem cellsHuman diabeticsWound healingMouse modelMarrow-derived mesenchymal stem cellsSimilar extentBone marrow-derived cellsNotch signalingHuman diabetic woundsDiabetic C57BL/6 miceAdipose-derived mesenchymal stem cellsCell survivalMarrow-derived cellsEndothelial cell densityDiabetic mouse modelNumber of macrophagesNude mouse modelTissue-derived stem cellsCD31-positive cellsCellular proliferationSmooth muscle cells
2002
PULMONARY TOXICITY OF SIMULATED LUNAR AND MARTIAN DUSTS IN MICE: I. HISTOPATHOLOGY 7 AND 90 DAYS AFTER INTRATRACHEAL INSTILLATION
Lam CW, James JT, McCluskey R, Cowper S, Balis J, Muro-Cacho C. PULMONARY TOXICITY OF SIMULATED LUNAR AND MARTIAN DUSTS IN MICE: I. HISTOPATHOLOGY 7 AND 90 DAYS AFTER INTRATRACHEAL INSTILLATION. Inhalation Toxicology 2002, 14: 901-916. PMID: 12396402, DOI: 10.1080/08958370290084683.Peer-Reviewed Original ResearchConceptsParticle-laden macrophagesPeribronchiolar inflammationLung lesionsPulmonary toxicityChronic pulmonary inflammationChronic inflammatory lesionsEvidence of inflammationAcute inflammatory responseNumber of macrophagesFocal alveolitisLung injurySeptal thickeningPulmonary inflammationInflammatory lesionsMild fibrosisExamination 7Chronic mildInflammatory responseAlveolitisFibrosisInflammationLungOverall severityMSS groupMice
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