2024
RESOLVING THE CHALLENGES OF BIG-DATA IMAGING GENETICS ANALYSIS TO UNDERSTAND GENETIC AND ENVIRONMENTAL RISK FACTORS IN PSYCHIATRIC DISORDERS
Kochunov P, Nichols T, Blangero J, Medland S, Glahn D, Hong E. RESOLVING THE CHALLENGES OF BIG-DATA IMAGING GENETICS ANALYSIS TO UNDERSTAND GENETIC AND ENVIRONMENTAL RISK FACTORS IN PSYCHIATRIC DISORDERS. European Neuropsychopharmacology 2024, 87: 21-22. DOI: 10.1016/j.euroneuro.2024.08.056.Peer-Reviewed Original ResearchGenetic analysisGenome-wide associationBrain patternsImaging genetic analysisImaging genetic datasetGenetic resolutionGenetic risk factorsGenetic datasetsGenetic dataDepressive disorderPsychiatric disordersRisk of development of dementiaVariance componentsHigh-resolution neuroimagingDevelopment of dementiaNurturing interactionsEnvironmental risk factorsAlzheimer's diseaseGenetic correlationsRisk factorsTreatment effectsDisordersLongitudinal datasetPsychosisSNPsBenchmarking Mendelian randomization methods for causal inference using genome-wide association study summary statistics
Hu X, Cai M, Xiao J, Wan X, Wang Z, Zhao H, Yang C. Benchmarking Mendelian randomization methods for causal inference using genome-wide association study summary statistics. American Journal Of Human Genetics 2024, 111: 1717-1735. PMID: 39059387, PMCID: PMC11339627, DOI: 10.1016/j.ajhg.2024.06.016.Peer-Reviewed Original ResearchConceptsMendelian randomizationMR methodsGenome-wide association study summary statisticsMendelian randomization methodsCausal inferenceInvalid instrumental variablesType I error controlInstrumental variablesCausal effect estimationIV assumptionsEffect estimatesSummary statisticsTwo-sampleGenetic variantsTrait pairsConfoundingGenetic datasetsGenetic dataConfounding scenariosRandomization methodInferencePractical guidanceSimulated datasetsGuidelinesStudy
2023
Genetic associations with longevity are on average stronger in females than in males
Zeng Y, Chen H, Liu X, Song Z, Yao Y, Lei X, Lv X, Cheng L, Chen Z, Bai C, Yin Z, Lv Y, Lu J, Li J, Land K, Yashin A, O'Rand A, Sun L, Yang Z, Tao W, Gu J, Gottschalk W, Tan Q, Christensen K, Hesketh T, Tian X, Yang H, Egidi V, Caselli G, Robine J, Wang H, Shi X, Vaupel J, Lutz M, Nie C, Min J. Genetic associations with longevity are on average stronger in females than in males. Heliyon 2023, 10: e23691. PMID: 38192771, PMCID: PMC10772631, DOI: 10.1016/j.heliyon.2023.e23691.Peer-Reviewed Original ResearchGenome-wide complex trait analysisGenome-wide association study datasetGenetic associationSex-specific genetic variantsSex-specific genesGenetic variantsComplex trait analysisReplication analysisPolygenic risk score analysisIndividual genesGenetic datasetsCandidate genesBiological functionsTrait analysisRisk score analysisGenesMiddle-age controlsLongevityIndependent datasetsLongevity StudyUnderlying mechanismGWASFuture investigationsVariantsSNPs
2020
Bayesian sparse heritability analysis with high-dimensional neuroimaging phenotypes
Zhao Y, Li T, Zhu H. Bayesian sparse heritability analysis with high-dimensional neuroimaging phenotypes. Biostatistics 2020, 23: 467-484. PMID: 32948880, PMCID: PMC9308456, DOI: 10.1093/biostatistics/kxaa035.Peer-Reviewed Original ResearchConceptsHeritability analysisHuman complex traitsLarge-scale phenotypeQuantitative geneticsComplex traitsPhenotypic variationTrait selectionGenetic datasetsSingle phenotypeDownstream analysisGenetic contributionHeritability estimationPhenotypeTraitsCentral roleNeuroimaging phenotypesUnited Kingdom BiobankHierarchical selectionPhenotypic methodsGeneticsHeritabilitySelectionVariationBrain variation
2010
Inference of Population History by Coupling Exploratory and Model-Driven Phylogeographic Analyses
Garrick R, Caccone A, Sunnucks P. Inference of Population History by Coupling Exploratory and Model-Driven Phylogeographic Analyses. International Journal Of Molecular Sciences 2010, 11: 1190-1227. PMID: 20480016, PMCID: PMC2871112, DOI: 10.3390/ijms11041190.Peer-Reviewed Original ResearchConceptsPhylogeographic analysisGene treesGenetic diversityConservation managementPopulation historyDNA sequencesGenetic datasetsGenetic dataCladistic analysisHistorical inferencesPopulation processesTemporal concordanceSynergistic interactionDiversitySpeciationSpatial distributionSequenceGeographic contextTrees
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