Antibody reactivity with new antigens revealed in multi‐transgenic triple knockout pigs may cause early loss of pig kidneys in baboons
Ariyoshi Y, Takeuchi K, Pomposelli T, Ekanayake‐Alper D, Shimizu A, Boyd L, Estime E, Ohta M, Asfour A, Arn J, Ayares D, Lorber M, Sykes M, Sachs D, Yamada K. Antibody reactivity with new antigens revealed in multi‐transgenic triple knockout pigs may cause early loss of pig kidneys in baboons. Xenotransplantation 2020, 28: e12642. PMID: 32909301, PMCID: PMC8957702, DOI: 10.1111/xen.12642.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsCytidine monophospho-N-acetylneuraminic acid hydroxylaseEndothelial protein C receptorTransgenic pigsMulti-transgenesPigsPre-screening assayPig kidneyGene editing technologyPig-to-baboonRenal functionKO pigsEditing technologyVascularized thymic graftsBaboon seraKnockout pigsStable renal functionGalT-KOHuman thrombomodulinMaintained renal functionBlood mononuclear cellsAcute xenograft rejectionProtein C receptorGenetic manipulationNatural antibodies
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