2011
The Impact of Childhood Maltreatment: A Review of Neurobiological and Genetic Factors
McCrory E, De Brito S, Viding E. The Impact of Childhood Maltreatment: A Review of Neurobiological and Genetic Factors. Frontiers In Psychiatry 2011, 2: 48. PMID: 21847382, PMCID: PMC3148713, DOI: 10.3389/fpsyt.2011.00048.Peer-Reviewed Original ResearchChildhood maltreatmentFunctional brain differencesFunctional MRI studyAdrenal axis stress responseCare-giving experienceMagnetic resonance imaging studyResonance imaging studyAtypical developmentEmotional developmentAtypical activationNeurobiological correlatesAmygdala hyperactivityBrain differencesFrontal regionsPsychiatric vulnerabilityEnvironmental adversityBehavioral studiesChildhood historyInformation biasesMaltreatmentPreliminary evidenceSuch experiencesStructural MRINeuroendocrine findingsSignificant risk factors
2010
Individuals Family History Positive for Alcoholism Show Functional Magnetic Resonance Imaging Differences in Reward Sensitivity That Are Related to Impulsivity Factors
Andrews MM, Meda SA, Thomas AD, Potenza MN, Krystal JH, Worhunsky P, Stevens MC, O'Malley S, Book GA, Reynolds B, Pearlson GD. Individuals Family History Positive for Alcoholism Show Functional Magnetic Resonance Imaging Differences in Reward Sensitivity That Are Related to Impulsivity Factors. Biological Psychiatry 2010, 69: 675-683. PMID: 21126735, PMCID: PMC3677031, DOI: 10.1016/j.biopsych.2010.09.049.Peer-Reviewed Original ResearchConceptsMonetary incentive delay taskIncentive delay taskNAcc activationReward anticipationDelay taskFamily history-positive individualsAbnormal reward processingRegional brain activationNucleus accumbens activationFunctional magnetic resonanceReward system activitySubstance-abusing individualsReward prospectReward sensitivityNeural correlatesImpulsivity constructsSubstance abuse historyImpulsivity factorsReward processingBehavioral impulsivityAtypical activationBrain activationOutcome phaseBiological predispositionTask phasesResearch Review: The neurobiology and genetics of maltreatment and adversity
McCrory E, De Brito SA, Viding E. Research Review: The neurobiology and genetics of maltreatment and adversity. Journal Of Child Psychology And Psychiatry 2010, 51: 1079-1095. PMID: 20546078, DOI: 10.1111/j.1469-7610.2010.02271.x.Peer-Reviewed Original ResearchConceptsChildhood maltreatmentEarly adversityFunctional brain differencesIndividual's genetic makeAdrenal axis stress responseAtypical developmentEmotional developmentNeurobiological developmentAtypical activationNeurobiological mechanismsBrain differencesPrefrontal cortexPsychiatric vulnerabilityEnvironmental experiencesAdversityEnvironmental adversityBrain regionsEarly stressMaltreatmentNeuroendocrine findingsChildrenAdultsCorpus callosumGenetic makeHuman studies
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