2024
An autoimmune transcriptional circuit drives FOXP3+ regulatory T cell dysfunction
Sumida T, Lincoln M, He L, Park Y, Ota M, Oguchi A, Son R, Yi A, Stillwell H, Leissa G, Fujio K, Murakawa Y, Kulminski A, Epstein C, Bernstein B, Kellis M, Hafler D. An autoimmune transcriptional circuit drives FOXP3+ regulatory T cell dysfunction. Science Translational Medicine 2024, 16: eadp1720. PMID: 39196959, PMCID: PMC12051482, DOI: 10.1126/scitranslmed.adp1720.Peer-Reviewed Original ResearchConceptsForkhead box P3Autoimmune diseasesCD4<sup>+</sup>Foxp3<sup>+</sup> regulatory T cellsMultiple sclerosisFoxp3<sup>+</sup> regulatory T cellsRegulatory T cell dysfunctionPR domain zinc finger protein 1Zinc finger protein 1Glucocorticoid-regulated kinase 1Regulatory T cellsT cell dysfunctionDisorder of young adultsAutoimmune disease multiple sclerosisDisease multiple sclerosisExpression of serumTranscriptional circuitsEpigenomic profilingShort isoformPrevent autoimmunityUpstream regulatorT cellsHuman autoimmunityEvolutionary emergenceKinase 1Molecular mechanisms
2022
Inhibition of renalase drives tumour rejection by promoting T cell activation
Guo X, Jessel S, Qu R, Kluger Y, Chen TM, Hollander L, Safirstein R, Nelson B, Cha C, Bosenberg M, Jilaveanu LB, Rimm D, Rothlin CV, Kluger HM, Desir GV. Inhibition of renalase drives tumour rejection by promoting T cell activation. European Journal Of Cancer 2022, 165: 81-96. PMID: 35219026, PMCID: PMC8940682, DOI: 10.1016/j.ejca.2022.01.002.Peer-Reviewed Original ResearchConceptsPD-1 inhibitorsMurine melanoma modelMelanoma-bearing miceMelanoma modelTumor microenvironmentTumor rejectionCell death protein 1 (PD-1) inhibitorsAnti-PD-1 activityEnhanced T cell infiltrationT cell-dependent fashionMelanoma cellsMelanoma tumor regressionPreclinical melanoma modelsT cell infiltrationNatural killer cellsForkhead box P3Expression of IFNγWild-type miceProtein 1 inhibitorT cell activationTumor cell contentWild-type melanoma cellsCD4 cellsAdvanced melanomaAntibody treatment
2020
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome: A systematic review
Park J, Lee K, Jeon B, Ochs H, Lee J, Gee H, Seo S, Geum D, Piccirillo C, Eisenhut M, van der Vliet H, Lee J, Kronbichler A, Ko Y, Shin J. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome: A systematic review. Autoimmunity Reviews 2020, 19: 102526. PMID: 32234571, DOI: 10.1016/j.autrev.2020.102526.Peer-Reviewed Original ResearchConceptsForkhead box P3IPEX patientsRisk of deathSkin manifestationsX-linked (IPEX) syndromeFactors associated with increased risk of deathFOXP3 mutationsCD4<sup>+</sup> regulatory TAssociated with increased risk of deathAssociated with better survivalResponse to treatment strategiesAssociated with increased riskAutoimmune hemolytic anemiaImmune-related complicationsGenotype-phenotype correlationLoss-of-function mutationsImmunosuppressive therapyRegulatory TPrognostic factorsIPEX syndromeRenal involvementAutoimmune phenomenaBetter survivalImmune dysregulationSeptic shock
2019
Regulatory T Cells in Respiratory Health and Diseases
Singh R, Alape D, de Lima A, Ascanio J, Majid A, Gangadharan S. Regulatory T Cells in Respiratory Health and Diseases. Pulmonary Medicine 2019, 2019: 1907807. PMID: 31827925, PMCID: PMC6886321, DOI: 10.1155/2019/1907807.Peer-Reviewed Original ResearchConceptsFactor forkhead box P3CD4+Foxp3+ T regulatory cellsTranscription factor forkhead box P3CD4+ T helper 1Immune responseMaintenance of immune toleranceRegulatory T cellsT regulatory cellsForkhead box P3T helper 1Transforming growth factor-betaAnti-inflammatory cytokinesGrowth factor-betaImmune toleranceImmune dysfunctionT cellsClinical impactAutoimmune diseasesTregsIL-10Clinical conditionsInflammatory conditionsFactor-betaTissue homeostasisDiseasePrognostic Impact of Tumor Cell Programmed Death Ligand 1 Expression and Immune Cell Infiltration in NSCLC
Edlund K, Madjar K, Mattsson J, Djureinovic D, Lindskog C, Brunnström H, Koyi H, Brandén E, Jirström K, Pontén F, Rahnenführer J, Micke P, Hengstler J. Prognostic Impact of Tumor Cell Programmed Death Ligand 1 Expression and Immune Cell Infiltration in NSCLC. Journal Of Thoracic Oncology 2019, 14: 628-640. PMID: 30639618, DOI: 10.1016/j.jtho.2018.12.022.Peer-Reviewed Original ResearchConceptsPD-L1 positivityOverall survivalLymphocyte infiltrationSmoking historyPD-L1Prognostic associationPlasma cellsProgrammed Death Ligand 1 ExpressionTumor PD-L1 positivityDeath ligand 1 (PD-L1) expressionAssociation of lymphocytePositive immune cellsLigand 1 expressionPD-L1 axisPD-L1 statusMultivariate Cox regressionDeath ligand 1Longer overall survivalForkhead box P3Immune cell infiltrationShorter overall survivalPatients' smoking historyKaplan-Meier plotsCheckpoint inhibitorsNSCLC patients
2018
FOXP3, RORγt and IL-10 cytokine profile in chronic heart failure.
Gorzin F, Amirzargar A, Mahmoudi M, Rahnemoon Z, Najmi Varzaneh F, Hedayat M, Sadati S, Eskandari V, Rahmati Z, Rezaei N. FOXP3, RORγt and IL-10 cytokine profile in chronic heart failure. Bratislava Medical Journal 2018, 118: 637-641. PMID: 29198133, DOI: 10.4149/bll_2017_122.Peer-Reviewed Original ResearchConceptsChronic heart failureIL-10 protein expressionIL-10CHF patientsHeart failurePathophysiology of CHFAcid receptor-related orphan receptor γtReceptor-related orphan receptor γtRetinoic acid receptor-related orphan receptor γtProtein expressionAnti-inflammatory cytokinesNon-ischemic causesForkhead box P3Role of Foxp3Supernatants of PBMCsIL-10 proteinOrphan receptor γtTreg cellsCytokine profileBox P3Genes Foxp3Inflammatory processT cellsHealthy subjectsStudy population
2013
Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses
Matarese G, Procaccini C, Menale C, Kim JG, Kim JD, Diano S, Diano N, De Rosa V, Dietrich MO, Horvath TL. Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 6193-6198. PMID: 23530205, PMCID: PMC3625304, DOI: 10.1073/pnas.1210644110.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAllelesAnimalsAntigensAutoimmunityCatalytic DomainEncephalomyelitis, Autoimmune, ExperimentalFlow CytometryFood DeprivationForkhead Transcription FactorsGenetic Predisposition to DiseaseHumansHungerHypothalamusInflammationMiceMice, KnockoutMice, TransgenicMyelin SheathNeuronsSirtuin 1T-Lymphocytes, RegulatoryThymus GlandConceptsRegulatory T cell responsesDelayed-type hypersensitivity responseHypothalamic feeding circuitsPeptide-expressing neuronsRegulatory T cellsSympathetic nervous systemT cell responsesForkhead box P3T helper 1Adaptive immune responsesWhole-body energy metabolismLow energy availabilityT cell activationAutoimmune disease susceptibilityBox P3Hypothalamic agoutiThymic generationHelper 1Hypersensitivity responseProinflammatory cytokinesHypothalamic neuronsSuppressive capacityT cellsImmune responseNervous system
2010
FOXP3+ regulatory T cells in the human immune system
Sakaguchi S, Miyara M, Costantino CM, Hafler DA. FOXP3+ regulatory T cells in the human immune system. Nature Reviews Immunology 2010, 10: 490-500. PMID: 20559327, DOI: 10.1038/nri2785.Peer-Reviewed Original ResearchConceptsForkhead box P3Human Treg cellsTreg cellsT cellsKey PointsRegulatory T (TReg) cellsTreg cell-based therapyAntitumour immune responseRegulatory T cellsExpression of CD45RAPromising therapeutic perspectiveHuman immune systemAutoimmune pathogenesisDominant toleranceBox P3HLA-DRCell-based therapiesAutoimmune diseasesImmune homeostasisImmune responseImmune diseasesSuppressive functionPotent mediatorCancer growthImmune systemTherapeutic perspectives
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