2022
Genetic tracing reveals transcription factor Foxp3-dependent and Foxp3-independent functionality of peripherally induced Treg cells
van der Veeken J, Campbell C, Pritykin Y, Schizas M, Verter J, Hu W, Wang Z, Matheis F, Mucida D, Charbonnier L, Chatila T, Rudensky A. Genetic tracing reveals transcription factor Foxp3-dependent and Foxp3-independent functionality of peripherally induced Treg cells. Immunity 2022, 55: 1173-1184.e7. PMID: 35700740, PMCID: PMC9885886, DOI: 10.1016/j.immuni.2022.05.010.Peer-Reviewed Original ResearchConceptsPTreg cellsTranscription factor Foxp3Treg cellsFactor Foxp3Absence of Foxp3Foxp3-independent mannerPeripheral Treg cellsRegulatory T cellsRole of Foxp3Genetic tracingSuppress autoimmunityTolerogenic signalsEffector TT cellsFoxp3Mature CD4Commensal microbiotaCell lineagesCellsCell expansionCell programTTregsColitisCD4Autoimmunity
2018
FOXP3, RORγt and IL-10 cytokine profile in chronic heart failure.
Gorzin F, Amirzargar A, Mahmoudi M, Rahnemoon Z, Najmi Varzaneh F, Hedayat M, Sadati S, Eskandari V, Rahmati Z, Rezaei N. FOXP3, RORγt and IL-10 cytokine profile in chronic heart failure. Bratislava Medical Journal 2018, 118: 637-641. PMID: 29198133, DOI: 10.4149/bll_2017_122.Peer-Reviewed Original ResearchConceptsChronic heart failureIL-10 protein expressionIL-10CHF patientsHeart failurePathophysiology of CHFAcid receptor-related orphan receptor γtReceptor-related orphan receptor γtRetinoic acid receptor-related orphan receptor γtProtein expressionAnti-inflammatory cytokinesNon-ischemic causesForkhead box P3Role of Foxp3Supernatants of PBMCsIL-10 proteinOrphan receptor γtTreg cellsCytokine profileBox P3Genes Foxp3Inflammatory processT cellsHealthy subjectsStudy population
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