2019
Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in Diabetes
Kunkemoeller B, Bancroft T, Xing H, Morris AH, Luciano AK, Wu J, Fernandez-Hernando C, Kyriakides TR. Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in Diabetes. Diabetes 2019, 68: 2016-2023. PMID: 31391172, PMCID: PMC6754242, DOI: 10.2337/db18-1001.Peer-Reviewed Original ResearchConceptsThrombospondin-2TSP2 expressionDiabetic control miceWound healingEffects of hyperglycemiaImpaired wound healingUnderlying pathological mechanismsDelayed Wound HealingMajor cellular sourceBlood vessel maturationGranulation tissue formationMajor complicationsDiabetic miceControl miceTreatment strategiesDiabetesPathological mechanismsDiabetic woundsAccelerated reepithelializationCellular sourceHigh glucoseHyperglycemiaMatricellular proteinExpression contributesHexosamine pathway
2006
Functional Analyses of Two Tomato APETALA3 Genes Demonstrate Diversification in Their Roles in Regulating Floral Development
de Martino G, Pan I, Emmanuel E, Levy A, Irish VF. Functional Analyses of Two Tomato APETALA3 Genes Demonstrate Diversification in Their Roles in Regulating Floral Development. The Plant Cell 2006, 18: 1833-1845. PMID: 16844904, PMCID: PMC1533988, DOI: 10.1105/tpc.106.042978.Peer-Reviewed Original ResearchConceptsCore eudicotsFloral developmentMADS-box transcription factorsDifferent expression domainsBox transcription factorFunctional differencesAP3 lineageAPETALA3 (AP3) geneEuAP3 lineageStamen identityAncestral roleStamen developmentHomeotic transformationsLineage genesExpression domainsBiochemical capabilitiesTranscription factorsFunctional analysisFunction mutationsGenesLineagesArabidopsisEudicotsEquivalent domainsExpression contributes
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