Srsf3-Dependent APA Drives Macrophage Maturation and Limits Atherosclerosis
Yang X, Zhang X, Tian Y, Yang J, Jia Y, Xie Y, Cheng L, Chen S, Wu L, Qin Y, Zhao Z, Zhao D, Wei Y. Srsf3-Dependent APA Drives Macrophage Maturation and Limits Atherosclerosis. Circulation Research 2025, 136: 985-1009. PMID: 40160097, DOI: 10.1161/circresaha.124.326111.Peer-Reviewed Original ResearchConceptsAlternative polyadenylationAssociated with atherosclerosis progressionUntranslated regionRNA sequencingExpression of chemokinesRegulation of cell fateAlternative polyadenylation patternsEfficient mitochondrial translationMetabolic labeling assaysSingle-cell RNA sequencingIntegrated stress responseMyeloid deletionLow-density lipoproteinMonocytes to macrophagesImpairment of protein synthesisPhagocytic impairmentMetabolomic profilesMacrophage maturationPrecursor nicotinamide mononucleotideCirculating monocytesIntegrated stress response inhibitorLesional cellsHistopathological analysisProatherosclerotic effectsNicotinamide mononucleotide treatment
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