2024
The Importance of PET Imaging to Understanding Whole-Body Cortisol Metabolism in Alzheimer’s Disease
Bini J. The Importance of PET Imaging to Understanding Whole-Body Cortisol Metabolism in Alzheimer’s Disease. Journal Of Alzheimer’s Disease 2024, 99: 113-115. PMID: 38607759, PMCID: PMC12425132, DOI: 10.3233/jad-231463.Peer-Reviewed Original ResearchEffects of prazosin treatment on liver enzymes are moderated by alcohol withdrawal symptoms in individuals with alcohol use disorder
Martins B, Fogelman N, Tate M, Hermes G, Sinha R. Effects of prazosin treatment on liver enzymes are moderated by alcohol withdrawal symptoms in individuals with alcohol use disorder. Alcohol Clinical And Experimental Research 2024, 48: 507-515. PMID: 38258493, PMCID: PMC10939766, DOI: 10.1111/acer.15263.Peer-Reviewed Original ResearchAlcohol withdrawal symptomsAlcohol use disorderEffect of prazosin treatmentWithdrawal symptomsPrazosin treatmentLiver enzyme levelsLiver enzymesAlanine transaminasePrazosin groupAlcohol drinking outcomesAspartate transaminaseGamma-glutamyltransferaseSeverity of AWSLiver enzymes alanine transaminaseWithdrawal severityDrinking outcomesElevated liver enzymesAUD treatmentTreatment effectsAmount of alcoholSignificant liver pathologyGamma-glutamyltransferase levelsEnzyme levelsRandomized Controlled TrialsDisordered background
2021
Stimulus‐Responsive Nanoparticles for Therapeutic Stabilization of Atherosclerosis
Mehta S, Ahamad N, Dewani M, Bhardwaj P, Banerjee R. Stimulus‐Responsive Nanoparticles for Therapeutic Stabilization of Atherosclerosis. 2021, 181-215. DOI: 10.1002/9783527832095.ch7.ChaptersAtherosclerosis treatmentPlaque sitesNon-selective accumulationElevated enzyme levelsOff-target toxicityTherapeutic stabilizationFree drug deliveryCardiovascular complicationsBlood flowAtherosclerosisTherapeutic outcomesFirst lineOxidative stressArtery wallEnzyme levelsExogenous strategiesProgressive accumulationApparent toxicityCellular debrisTreatmentEndogenous triggersStimuli-responsive nanoparticle systemToxicitySuccessful deliveryDrug-loaded nanoparticles
2017
Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice
Klein ZA, Takahashi H, Ma M, Stagi M, Zhou M, Lam TT, Strittmatter SM. Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice. Neuron 2017, 95: 281-296.e6. PMID: 28728022, PMCID: PMC5558861, DOI: 10.1016/j.neuron.2017.06.026.Peer-Reviewed Original ResearchConceptsLysosomal protein levelsFrontotemporal lobar degenerationProtein levelsMultiple lysosomal enzymesLysosomal enzymesV0 subunitsTMEM106B geneProteomic analysisProgranulin-deficient miceExtent of neurodegenerationCommon neurodegenerative disorderLysosomal acidificationLysosomal enzyme levelsProtein 1Microglial accumulationRisk modificationFTLD riskBehavioral abnormalitiesRetinal degenerationNeurodegenerative disordersFrontotemporal dementiaGRNTMEM106BFunctional relationshipEnzyme levels
2008
The ontogeny of drug metabolism enzymes and implications for adverse drug events
Hines R. The ontogeny of drug metabolism enzymes and implications for adverse drug events. Pharmacology & Therapeutics 2008, 118: 250-267. PMID: 18406467, DOI: 10.1016/j.pharmthera.2008.02.005.Peer-Reviewed Original ResearchConceptsAdverse drug eventsDrug eventsDrug metabolism enzymesDME groupPediatric patientsThird trimesterCurrent knowledgeFirst trimesterDrug therapyDrug dispositionPharmacokinetic modelLow levelsEnzyme levelsTrimesterEnzyme expressionGestationSecond groupFetusesMetabolism enzymesBirthPhysiological factorsDevelopmental expression patternsMinimal changesReviewGroup
2005
Impact of Humoral Immune Response on Distribution and Efficacy of Recombinant Adeno-Associated Virus-Derived Acid -Glucosidase in a Model of Glycogen Storage Disease Type II
Cresawn K, Fraites T, Wasserfall C, Atkinson M, Lewis M, Porvasnik S, Liu C, Mah C, Byrne B. Impact of Humoral Immune Response on Distribution and Efficacy of Recombinant Adeno-Associated Virus-Derived Acid -Glucosidase in a Model of Glycogen Storage Disease Type II. Human Gene Therapy 2005, 16: 68-80. PMID: 15703490, DOI: 10.1089/hum.2005.16.68.Peer-Reviewed Original ResearchConceptsGlycogen storage disease type IIImmune-tolerant miceStorage disease type IIAntibody responseContractile functionImmune responseHumoral immune responseHind limb musclesAcid alpha-glucosidaseCardiorespiratory failureType IIAntibody formationReduced glycogenGlycogen reductionLysosomal storage diseaseSoleus muscleGAA levelsMiceEnzyme levelsSkeletal muscleStorage diseaseLevel of activityMuscleRecombinant adenoAlpha-glucosidase
2001
Newly Diagnosed Pulmonary Sarcoidosis in HIV-infected Patients
Haramati L, Lee G, Singh A, Molina P, White C. Newly Diagnosed Pulmonary Sarcoidosis in HIV-infected Patients. Radiology 2001, 218: 242-246. PMID: 11152809, DOI: 10.1148/radiology.218.1.r01ja25242.Peer-Reviewed Original ResearchConceptsCD4 cell countFocal consolidationCell countPulmonary sarcoidosisReticular opacitiesGranular opacitiesChest radiographsPulmonary nodulesMean CD4 cell countAngiotensin-converting enzyme levelsEnzyme levelsActive antiretroviral therapyGround-glass opacitiesHuman immunodeficiency virusChest CT scanFindings of sarcoidosisManifestations of diseasePulmonary signsTen HIVAntiretroviral therapyRadiologic featuresClinical featuresImmunodeficiency virusRadiographic findingsTomographic scan
1994
The effect of methylprednisolone, naloxone, and spinal cord trauma on four liver enzymes: observations from NASCIS 2
Shepard M, Bracken M. The effect of methylprednisolone, naloxone, and spinal cord trauma on four liver enzymes: observations from NASCIS 2. Spinal Cord 1994, 32: 236-245. PMID: 8022633, DOI: 10.1038/sc.1994.43.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCord injuryLiver enzymesDrug protocolsNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudySpinal Cord Injury StudyStudy drug infusionEnzyme levelsLiver enzyme levelsEffect of methylprednisoloneSpinal cord traumaDays post infusionSeverity of injuryTotal bilirubin testsSteroid protocolCord traumaLiver functionSpinal cordDrug infusionPost infusionInjury studiesLarge dosesBilirubin testInjury
1988
Liver disease associated with occupational exposure to the solvent dimethylformamide.
REDLICH C, BECKETT W, SPARER J, BARWICK K, RIELY C, MILLER H, SIGAL S, SHALAT S, CULLEN M. Liver disease associated with occupational exposure to the solvent dimethylformamide. Annals Of Internal Medicine 1988, 108: 680-6. PMID: 3358569, DOI: 10.7326/0003-4819-108-5-680.Peer-Reviewed Original ResearchConceptsToxic liver diseaseLiver enzyme abnormalitiesLiver diseaseEnzyme abnormalitiesAspartate aminotransferaseALT levelsBiopsy specimensStandard liver function testsAppropriate skin protectionClinical-epidemiological investigationNegative viral serologyOccupational liver diseaseSymptoms of hepatitisEnzyme levelsLiver function testsLiver biopsy specimensRatio of ASTToxic liver injuryOccupational medicine clinicExtensive clinical evaluationAcademic medical centerViral serologyAminotransferase levelsMost patientsLiver injury
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