2024
A human autoimmune organoid model reveals IL-7 function in coeliac disease
Santos A, van Unen V, Lin Z, Chirieleison S, Ha N, Batish A, Chan J, Cedano J, Zhang E, Mu Q, Guh-Siesel A, Tomaske M, Colburg D, Varma S, Choi S, Christophersen A, Baghdasaryan A, Yost K, Karlsson K, Ha A, Li J, Dai H, Sellers Z, Chang H, Dunn J, Zhang B, Mellins E, Sollid L, Fernandez-Becker N, Davis M, Kuo C. A human autoimmune organoid model reveals IL-7 function in coeliac disease. Nature 2024, 632: 401-410. PMID: 39048815, PMCID: PMC11747932, DOI: 10.1038/s41586-024-07716-2.Peer-Reviewed Original ResearchMeSH KeywordsAutoantibodiesAutoimmunityB-LymphocytesBiopsyCeliac DiseaseDuodenumEpitopesGlutensGTP-Binding ProteinsHLA-DQ AntigensHumansInterleukin-7Intestinal MucosaKiller Cells, NaturalModels, BiologicalMyeloid CellsOrganoidsProtein Glutamine gamma Glutamyltransferase 2Receptors, Antigen, B-CellReceptors, Antigen, T-CellT-LymphocytesConceptsInterleukin-7Major histocompatibility complexT cellsEpithelial destructionNatural killer (NK) cellsCoeliac diseaseTissue-resident immune cellsB cell receptor repertoiresOrganoid modelsModels of autoimmunityAir-liquid interfaceGluten-free dietActive CeDRemission diseaseIn vitro modelImmune microenvironmentEndoscopic biopsyMyeloid subsetsAutoantibody productionMyeloid cellsPatient biopsiesHLA-DQ8Immune cellsAnti-transglutaminasePlasma cellsClinical Decision Making in Inflammatory Bowel Disease Mimics: Practice Management from Inflammatory Bowel Disease LIVE
Fiske H, Ward C, Shah S, Holubar S, Al-Bawardy B, Barnes E, Binion D, Bohm M, Brand M, Clarke K, Cohen B, Cross R, Dueker J, Engels M, Farraye F, Fine S, Forster E, Gaidos J, Ginsburg P, Goyal A, Hanson J, Herfath H, Hull T, Kelly C, Lazarev M, Levy L, Melia J, Philpott J, Qazi T, Siegel C, Watson A, Wexner S, Williams E, Regueiro M. Clinical Decision Making in Inflammatory Bowel Disease Mimics: Practice Management from Inflammatory Bowel Disease LIVE. Crohn's & Colitis 360 2024, 6: otae022. PMID: 38720935, PMCID: PMC11078036, DOI: 10.1093/crocol/otae022.Peer-Reviewed Original ResearchInflammatory bowel diseaseReview of patient historyPresentation of inflammatory bowel diseaseInflammatory bowel disease patientsTreated with biologicsCost of patient careClinical management implicationsReassessment of treatmentIBD specialistsClinical responseMedication-inducedIBD patientsPrescribed steroidsPatient careEndoscopic biopsyTherapeutic workupMultidisciplinary managementIBD casesBalloon enteroscopyAdverse eventsDifferential diagnosisDisease mimicsDiverse presentationsPatient historyBowel disease
2022
Rare presentation of angiomatosis in the paranasal sinuses mimicking juvenile nasopharyngeal angiofibroma in a 16 year old male
Suresh N, Shah V, Matichak D, Ghiam M, Pasick L, Abecassis I, Saad A, Morcos J, Sargi Z, Bhatia R. Rare presentation of angiomatosis in the paranasal sinuses mimicking juvenile nasopharyngeal angiofibroma in a 16 year old male. Radiology Case Reports 2022, 17: 3527-3534. PMID: 35923345, PMCID: PMC9340122, DOI: 10.1016/j.radcr.2022.07.031.Peer-Reviewed Original ResearchJuvenile nasopharyngeal angiofibromaParanasal sinusesSkull baseRare presentationNasopharyngeal angiofibromaHistory of presentationTertiary care centerBroad differential diagnosisInternal maxillary arteryYear old maleSkull base massAdjacent paranasal sinusesFinal pathologyPreoperative embolizationLateral gazeTransphenoidal resectionClinical outcomesEndoscopic biopsyVisual acuitySurgical interventionVascular tumorsEmergency roomSubjective diplopiaCare centerCavernous sinus
2018
Hemolytic Anemia and Gastric Carcinoid in a Russian Seafarer: Highlighting the Role of Diagnostic Technologies in Modern Clinical Practice.
Chaunzwa TL, O'Shea J, Boggs NA, Schwartz JI, Gibson J, Gielissen KA. Hemolytic Anemia and Gastric Carcinoid in a Russian Seafarer: Highlighting the Role of Diagnostic Technologies in Modern Clinical Practice. The Yale Journal Of Biology And Medicine 2018, 91: 243-246. PMID: 30258311, PMCID: PMC6153615.Peer-Reviewed Case Reports and Technical NotesConceptsAutoimmune gastritisNeurologic functionGastric carcinoidsPernicious anemiaHemolytic anemiaElevated lactate dehydrogenase levelMicroangiopathic hemolytic anemiaGastric carcinoid tumorsLactate dehydrogenase levelsNormal neurologic functionDifferent medical specialistsModern clinical practiceHealth insurance providersMicroangiopathic anemiaRepeat endoscopyAtypical presentationCarcinoid tumorsEndoscopic biopsyMapping biopsyTumor burdenIntramedullary hemolysisLow haptoglobinDehydrogenase levelsOccupational exposureReticulocyte count
2016
Evaluating Intestinal Infections
Barbieri A, West AB. Evaluating Intestinal Infections. Advances In Anatomic Pathology 2016, 23: 135-143. PMID: 27058242, DOI: 10.1097/pap.0000000000000111.Peer-Reviewed Original ResearchConceptsDifferential diagnosisEvidence of infectionEndoscopic biopsyIntestinal infectionsMucosal infectionsIntestinal mucosaHost reactionSmall intestineInfectious entitiesHistologic sectionsMorphologic compartmentsMucosaInfectionDiagnosisPathologistsPresent studyAutoimmuneCompartmentsBiopsyIntestine
2011
Molecular Classification of Gastric Cancer: A New Paradigm
Shah M, Khanin R, Tang L, Janjigian Y, Klimstra D, Gerdes H, Kelsen D. Molecular Classification of Gastric Cancer: A New Paradigm. Clinical Cancer Research 2011, 17: 2693-2701. PMID: 21430069, PMCID: PMC3100216, DOI: 10.1158/1078-0432.ccr-10-2203.Peer-Reviewed Original ResearchConceptsGastric cancer subtypesGastric cancerCancer subtypesClassification of gastric cancerLocalized gastric adenocarcinomaPreoperative clinical trialLocalized gastric cancerSubtypes of gastric cancerDistal gastric cancerExpression analysisCDNA expression analysisIdentified several pathwaysTargeted biopsyPrimary tumorEndoscopic biopsyGastric adenocarcinomaHistological distinctionUnique epidemiologyClinical trialsBioconductor R packageAdequate RNAGene set analysisAnatomical criteriaGene expression dataMolecular drivers
2007
Evaluation of the feasibility of expression microarray analysis in endoscopically obtained biopsies of gastric carcinoma and their clinical applicability
Jhawer M, Qin L, Gerdes H, Klimstra D, Schattner M, Viale A, Gonen M, Schwartz G, Kelsen D, Shah M. Evaluation of the feasibility of expression microarray analysis in endoscopically obtained biopsies of gastric carcinoma and their clinical applicability. Journal Of Clinical Oncology 2007, 25: 21164-21164. DOI: 10.1200/jco.2007.25.18_suppl.21164.Peer-Reviewed Original ResearchEndoscopic biopsyExpression microarray analysisGastric cancerLauren classificationGastric carcinomaGene expression profilesMicroarray analysisExpression analysisGastroesophageal junction adenocarcinomaFresh tumor tissueDiffuse gastric cancerNCI-sponsored trialsExpression profilesThreshold p <Probe setsLauren histologyJunction adenocarcinomaPathology reviewTumor specimensCisplatin chemotherapyDifferential gene expression profilesGene probe setsTumor tissuesIntestinal-typeBiopsyDiagnostic approach to a patient with atypical Henoch-Schönlein purpura
Shin J, Lee J. Diagnostic approach to a patient with atypical Henoch-Schönlein purpura. Endoscopy 2007, 39: 571-571. PMID: 17554658, DOI: 10.1055/s-2007-966491.Peer-Reviewed Original ResearchConceptsHenoch-Schonlein purpuraMethylprednisolone pulse therapyPolyangitis overlap syndromeAcute renal failureFactor XIII activityAbdominal painSkin rashRenal failureOverlap syndromeIgA depositionSystemic vasculitisHemorrhagic ascitesEndoscopic biopsyNonspecific inflammationPolyarteritis nodosaFatal outcomeDiagnosis of Henoch-Schonlein purpuraAbsence of abdominal painProgressive acute renal failureAbdominopelvic computed tomographyAcute multiple infarctsCourse of vasculitisTime of admissionComplained of arthralgiaPredominant IgA deposition
2005
The effect of GI bleeding on Helicobacter pylori diagnostic testing: a prospective study at the time of bleeding and 1 month later
Laine LA, Nathwani RA, Naritoku W. The effect of GI bleeding on Helicobacter pylori diagnostic testing: a prospective study at the time of bleeding and 1 month later. Gastrointestinal Endoscopy 2005, 62: 853-859. PMID: 16301025, DOI: 10.1016/j.gie.2005.09.019.Peer-Reviewed Original ResearchConceptsH pylori densityAcute GI bleedingInflammatory cell infiltrationH pyloriGI bleedingHistologic examinationCohort studyCell infiltrationDiagnostic testingBlinded histologic examinationH pylori testingAcute variceal bleedingProspective cohort studyUrban county hospitalProton pump inhibitorsTime of bleedingRapid urease testingVariceal bleedingCase seriesEndoscopic biopsyProspective studyPump inhibitorsBiopsy specimensUrease testingCounty Hospital
2002
Helicobacter pylori eradication does not worsen quality of life related to reflux symptoms: a prospective trial
Laine L, Dhir V. Helicobacter pylori eradication does not worsen quality of life related to reflux symptoms: a prospective trial. Alimentary Pharmacology & Therapeutics 2002, 16: 1143-1148. PMID: 12030957, DOI: 10.1046/j.1365-2036.2002.01267.x.Peer-Reviewed Original ResearchMeSH Keywords2-PyridinylmethylsulfinylbenzimidazolesAdultAmoxicillinAnti-Bacterial AgentsAnti-Ulcer AgentsBreath TestsClarithromycinDrug Therapy, CombinationDyspepsiaFemaleGastroesophageal RefluxHelicobacter InfectionsHumansLansoprazoleMaleMiddle AgedOmeprazolePenicillinsProspective StudiesQuality of LifeUreaConceptsGastro-oesophageal reflux diseaseQuality of lifeH. pylori therapyPylori therapyReflux diseaseH. pyloriSymptomatic gastro-oesophageal reflux diseaseHelicobacter pylori eradicationHelicobacter pylori therapyPopulation of patientsEnd of therapyUrea breath testReflux symptomsPylori eradicationTriple therapyProspective trialEndoscopic biopsyPrimary complaintProspective studyLife QuestionnaireBreath testPatientsTherapyMonthsSymptoms
2000
The quality of care for medicare patients with peptic ulcer disease
Marshall B, Stevens B, Cangialose C, Bratzler D, Ballard D, FitzGerald D, Etchason J, Herrin J, Culpepper-Morgan J, Ofman J, Elward K, Alexander W. The quality of care for medicare patients with peptic ulcer disease. The American Journal Of Gastroenterology 2000, 95: 106. PMID: 10638567, DOI: 10.1111/j.1572-0241.2000.01514.x.Peer-Reviewed Original ResearchConceptsPeptic ulcer diseaseQuality of careHospitalized Medicare beneficiariesUlcer diseaseNSAID useH. pyloriUlcer patientsUlcer riskMedicare beneficiariesNonsteroidal anti-inflammatory drug useAnti-inflammatory drug useH. pylori-positive patientsMedical record reviewPylori-positive patientsMedicare claim filesSample of inpatientsAppropriate therapyEndoscopic biopsyPeer review organizationsRecord reviewOutpatient recordsCare indicatorsPrincipal diagnosisMedicare patientsPatients
1999
Once-daily therapy for H. pylori infection: a randomized comparison of four regimens
Laine L, Estrada R, Trujillo M, Cheybani K, Yeramian P, Smith S, Neil G. Once-daily therapy for H. pylori infection: a randomized comparison of four regimens. The American Journal Of Gastroenterology 1999, 94: 962. PMID: 10201465, DOI: 10.1111/j.1572-0241.1999.995_r.x.Peer-Reviewed Original ResearchConceptsH. pylori infectionEradication ratePylori infectionExtended-release formulationDaily therapyBreath testDaily triple therapyHigh-dose omeprazoleTreat eradication ratesCompletion of therapyHelicobacter pylori infectionRepeat breath testStudy medicationTriple therapyEndoscopic biopsyRandomized comparisonLack of complianceTherapyPilot studyInfectionFurther studiesClarithromycinOmamDaysSubjects
1998
An office-based whole blood test is preferable to a laboratory quantitative serology test in the determination of Helicobacter pylori infection documented by endoscopic biopsy
Knigge K, Fennerty M, Faigel D, Magaret N, Marquis S, Vartan G, Laine L. An office-based whole blood test is preferable to a laboratory quantitative serology test in the determination of Helicobacter pylori infection documented by endoscopic biopsy. Gastroenterology 1998, 114: a180. DOI: 10.1016/s0016-5085(98)80731-2.Peer-Reviewed Original Research
1996
The influence of size or number of biopsies on rapid urease test results: a prospective evaluation
Laine L, Chun D, Stein C, El-Beblawi I, Sharma V, Chandrasoma P. The influence of size or number of biopsies on rapid urease test results: a prospective evaluation. Gastrointestinal Endoscopy 1996, 43: 49-53. PMID: 8903818, DOI: 10.1016/s0016-5107(96)70260-2.Peer-Reviewed Original ResearchConceptsRegular biopsiesPositive testJumbo biopsyForceps biopsyAmount of tissueRapid urease test resultsHelicobacter pylori infectionNumber of biopsiesRapid urease testingUrease test resultsValuable diagnostic toolEndoscopic biopsyProspective evaluationPylori infectionUrease testingDiagnostic yieldHistologic examinationUrease testBiopsyRapid ureasePatientsFalse negative rateDiagnostic testsInterobserver agreementMean time
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