2017
Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys
Tietjen GT, Hosgood SA, DiRito J, Cui J, Deep D, Song E, Kraehling JR, Piotrowski-Daspit AS, Kirkiles-Smith NC, Al-Lamki R, Thiru S, Bradley JA, Saeb-Parsy K, Bradley JR, Nicholson ML, Saltzman WM, Pober JS. Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys. Science Translational Medicine 2017, 9 PMID: 29187644, PMCID: PMC5931373, DOI: 10.1126/scitranslmed.aam6764.Peer-Reviewed Original ResearchConceptsNormothermic machine perfusionEndothelial cellsAlloimmune responseMachine perfusionEx vivo normothermic machine perfusionImmune systemHuman kidneyIschemia-reperfusion injuryRecipient's immune systemHost alloimmune responsesAnti-CD31 antibodyNew clinical strategiesPreclinical human studiesVascular endothelial cellsSystemic drug deliveryAntidonor antibodiesRenal vasculatureLong-term benefitsEC injuryTarget cell typeClinical strategiesHuman studiesTherapeutic potentialViable organsInjury
2006
Endothelial Cell Dysfunction, Injury and Death
Pober JS, Min W. Endothelial Cell Dysfunction, Injury and Death. Handbook Of Experimental Pharmacology 2006, 176/II: 135-156. PMID: 16999227, DOI: 10.1007/3-540-36028-x_5.Peer-Reviewed Original ResearchConceptsTumor necrosis factorCytolytic T lymphocytesEC injuryEndothelial cellsReactive oxygen speciesEndothelial cell dysfunctionMacrophage-derived cytokinesVascular endothelial cellsEndothelial dysfunctionNecrosis factorCell dysfunctionT lymphocytesInjuryCommon mediatorInflammationDysfunctionDeathOxygen speciesCytokinesLymphocytesNeutrophilsDifferent agentsBiochemical pathways
1998
The differential effect of contrast agents on endothelial cell and smooth muscle cell growth in vitro
Sawmiller C, Powell R, Quader M, Dudrick S, Sumpio B. The differential effect of contrast agents on endothelial cell and smooth muscle cell growth in vitro. Journal Of Vascular Surgery 1998, 27: 1128-1140. PMID: 9652475, DOI: 10.1016/s0741-5214(98)70015-1.Peer-Reviewed Original ResearchConceptsNonionic contrastEndothelial cellsIonic contrastSmooth muscle cell proliferationSignificant decreaseSmooth muscle cell growthNonionic contrast agentsCultured bovine aorta endothelial cellsMuscle cell proliferationBrief exposureMuscle cell growthRole of osmolalityContrast exposureEC injuryContrast agentsAorta endothelial cellsLength of exposureDay 3SMC proliferationOsmolar effectsBovine aorta endothelial cellsEffect of contrastCell proliferationConfluent endothelial cellsOsmolar solution
1997
Evidence that tumor necrosis factor triggers apoptosis in human endothelial cells by interleukin-1-converting enzyme-like protease-dependent and -independent pathways.
Slowik MR, Min W, Ardito T, Karsan A, Kashgarian M, Pober JS. Evidence that tumor necrosis factor triggers apoptosis in human endothelial cells by interleukin-1-converting enzyme-like protease-dependent and -independent pathways. Laboratory Investigation 1997, 77: 257-67. PMID: 9314949.Peer-Reviewed Original ResearchConceptsHuman endothelial cellsBcl-xLEndothelial cellsEnzyme-like proteasesType 1 TNF receptorBcl-2Antiapoptotic protein Bcl-2Protein synthesis inhibitor cycloheximideProtein Bcl-2CrmA proteinTumor necrosis factorCombination of TNFCultured human endothelial cellsZ-VADTriggers apoptosisSeparable pathwaysIndependent pathwaysTNF muteinsInhibitor cycloheximideProtein A20Necrosis factorEC injuryTNFApoptosisTNF receptor
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