1997
Suppression of neuronal apoptosis by S-nitrosylation of caspases
Tenneti L, D'Emilia D, Lipton S. Suppression of neuronal apoptosis by S-nitrosylation of caspases. Neuroscience Letters 1997, 236: 139-142. PMID: 9406756, DOI: 10.1016/s0304-3940(97)00780-5.Peer-Reviewed Original ResearchConceptsS-nitrosylationInterleukin-1beta-converting enzyme-like proteasesCritical cysteine residuesEnzyme-like proteasesApoptotic cell deathHuman embryonic kidneyTranscription factorsEnzyme familyCysteine residuesG proteinsEmbryonic kidneyCell deathCaspasesIon channelsPrimary cerebrocortical neuronsPhysiological activityEnzyme activityActive siteApoptosisNeuronal apoptosisCerebrocortical neuronsFamilyProteinProteaseEnzymeEvidence that tumor necrosis factor triggers apoptosis in human endothelial cells by interleukin-1-converting enzyme-like protease-dependent and -independent pathways.
Slowik MR, Min W, Ardito T, Karsan A, Kashgarian M, Pober JS. Evidence that tumor necrosis factor triggers apoptosis in human endothelial cells by interleukin-1-converting enzyme-like protease-dependent and -independent pathways. Laboratory Investigation 1997, 77: 257-67. PMID: 9314949.Peer-Reviewed Original ResearchConceptsHuman endothelial cellsBcl-xLEndothelial cellsEnzyme-like proteasesType 1 TNF receptorBcl-2Antiapoptotic protein Bcl-2Protein synthesis inhibitor cycloheximideProtein Bcl-2CrmA proteinTumor necrosis factorCombination of TNFCultured human endothelial cellsZ-VADTriggers apoptosisSeparable pathwaysIndependent pathwaysTNF muteinsInhibitor cycloheximideProtein A20Necrosis factorEC injuryTNFApoptosisTNF receptor
1996
A cleavage-site-directed inhibitor of interleukin-1β-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes
Kelvin C, INAYAT-HUSSAIN S, COUET C, COHEN G. A cleavage-site-directed inhibitor of interleukin-1β-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes. Biochemical Journal 1996, 314: 27-32. PMID: 8660294, PMCID: PMC1217036, DOI: 10.1042/bj3140027.Peer-Reviewed Original ResearchConceptsEnzyme-like proteasesInterleukin-1beta-converting enzyme-like proteasesChromatin condensationConventional gel electrophoresisDNA cleavageCell detachmentGrowth factor beta1Gel electrophoresisPrimary hepatocytesApoptosisProteasePrimary culturesRat hepatocytesLiver apoptosisInhibitorsStaurosporineHepatocytesEnzyme
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