2013
Lasalocid induces apoptosis via the cell cycle arrest and ROS‐mediated mitochondrial pathway in prostate cancer PC‐3 cells
Kim K, Kim S, Yu S, Park S, Kong2 I, Ahn S. Lasalocid induces apoptosis via the cell cycle arrest and ROS‐mediated mitochondrial pathway in prostate cancer PC‐3 cells. The FASEB Journal 2013, 27: lb206-lb206. DOI: 10.1096/fasebj.27.1_supplement.lb206.Peer-Reviewed Original ResearchProstate cancer cellsHuman prostate cancer cellsCancer cellsPC-3 cellsCaspase-3 substrateMitochondrial membrane hyperpolarizationCaspase-dependent apoptosisMitochondrial membrane potentialCell cycle arrestProstate cancer PC-3 cellsCancer PC-3 cellsMitochondrial pathwayIntracellular ROS levelsTriggers apoptosisLevels of BaxPARP-1Cycle arrestSignal pathwayAssociated signal pathwayROS levelsCaspase-3Bcl-2ApoptosisElevated oxidative stressMembrane potential
2010
PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer
VanHouten J, Sullivan C, Bazinet C, Ryoo T, Camp R, Rimm DL, Chung G, Wysolmerski J. PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 11405-11410. PMID: 20534448, PMCID: PMC2895115, DOI: 10.1073/pnas.0911186107.Peer-Reviewed Original ResearchConceptsPMCA2 expressionBreast cancerT47D breast cancer cellsIntracellular calcium levelsBreast cancer progressionBreast cancer cellsEpithelial cell apoptosisPoor outcomeIntracellular calciumCalcium levelsMammary gland involutionCancer progressionCell apoptosisCancer cellsMammary involutionApoptosisGland involutionCancerMammary epithelial cell apoptosisOutcomesPMCA2Triggers apoptosisApical surfaceExpressionOverexpression
1997
Evidence that tumor necrosis factor triggers apoptosis in human endothelial cells by interleukin-1-converting enzyme-like protease-dependent and -independent pathways.
Slowik MR, Min W, Ardito T, Karsan A, Kashgarian M, Pober JS. Evidence that tumor necrosis factor triggers apoptosis in human endothelial cells by interleukin-1-converting enzyme-like protease-dependent and -independent pathways. Laboratory Investigation 1997, 77: 257-67. PMID: 9314949.Peer-Reviewed Original ResearchConceptsHuman endothelial cellsBcl-xLEndothelial cellsEnzyme-like proteasesType 1 TNF receptorBcl-2Antiapoptotic protein Bcl-2Protein synthesis inhibitor cycloheximideProtein Bcl-2CrmA proteinTumor necrosis factorCombination of TNFCultured human endothelial cellsZ-VADTriggers apoptosisSeparable pathwaysIndependent pathwaysTNF muteinsInhibitor cycloheximideProtein A20Necrosis factorEC injuryTNFApoptosisTNF receptor
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply