Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys
Tietjen GT, Hosgood SA, DiRito J, Cui J, Deep D, Song E, Kraehling JR, Piotrowski-Daspit AS, Kirkiles-Smith NC, Al-Lamki R, Thiru S, Bradley JA, Saeb-Parsy K, Bradley JR, Nicholson ML, Saltzman WM, Pober JS. Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys. Science Translational Medicine 2017, 9 PMID: 29187644, PMCID: PMC5931373, DOI: 10.1126/scitranslmed.aam6764.Peer-Reviewed Original ResearchConceptsNormothermic machine perfusionEndothelial cellsAlloimmune responseMachine perfusionEx vivo normothermic machine perfusionImmune systemHuman kidneyIschemia-reperfusion injuryRecipient's immune systemHost alloimmune responsesAnti-CD31 antibodyNew clinical strategiesPreclinical human studiesVascular endothelial cellsSystemic drug deliveryAntidonor antibodiesRenal vasculatureLong-term benefitsEC injuryTarget cell typeClinical strategiesHuman studiesTherapeutic potentialViable organsInjury
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