2025
P-788. Exploring β-Lactam Interactions with DacB1: Unraveling Optimal Therapies for Combating Drug-Resistant Mycobacterium tuberculosis
Nantongo M, Nguyen D, Shin E, Bethel C, Taracila M, Dousa K, Kurz S, Nguyen L, Kreiswirth B, Boom W, Bonomo R. P-788. Exploring β-Lactam Interactions with DacB1: Unraveling Optimal Therapies for Combating Drug-Resistant Mycobacterium tuberculosis. Open Forum Infectious Diseases 2025, 12: ofae631.982. PMCID: PMC11778675, DOI: 10.1093/ofid/ofae631.982.Peer-Reviewed Original ResearchMinimum inhibitory concentrationAcyl-enzyme adductOxyanion holeB-lactamB-lactamasePeptidoglycan synthesis pathwayCarbonyl groupHydrophobic interactionsElectrospray ionization mass spectrometryAcyl-enzyme formationB-lactam antibioticsMichaelis-Menten complexC1‐methyl groupProtein motifsPeptidoglycan biosynthesisDrug-resistant Mycobacterium tuberculosisIonization mass spectrometryPeptidoglycan synthesisD-carboxypeptidaseAnalysis of meropenemB-lactamase inhibitorsClinical isolatesBroth microdilutionClinically achievable concentrationsSynthesis pathway
2019
Transmissibility and potential for disease progression of drug resistant Mycobacterium tuberculosis: prospective cohort study
Becerra MC, Huang CC, Lecca L, Bayona J, Contreras C, Calderon R, Yataco R, Galea J, Zhang Z, Atwood S, Cohen T, Mitnick CD, Farmer P, Murray M. Transmissibility and potential for disease progression of drug resistant Mycobacterium tuberculosis: prospective cohort study. The BMJ 2019, 367: l5894. PMID: 31649017, PMCID: PMC6812583, DOI: 10.1136/bmj.l5894.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntitubercular AgentsChildChild, PreschoolContact TracingDisease ProgressionFemaleFollow-Up StudiesHumansIncidenceInfantInfant, NewbornIsoniazidKaplan-Meier EstimateMaleMicrobial Sensitivity TestsMiddle AgedMycobacterium tuberculosisPeruProspective StudiesRifampinSputumTuberculin TestTuberculosis, Multidrug-ResistantTuberculosis, PulmonaryYoung AdultConceptsDrug-sensitive tuberculosisMultidrug-resistant tuberculosisHousehold contactsProspective cohort studySensitive tuberculosisTuberculosis infectionResistant tuberculosisCohort studyTuberculosis diseaseHigh riskDrug-resistant Mycobacterium tuberculosisIncident tuberculosis diseasePhenotypic drug resistanceDistrict Health CenterResistant Mycobacterium tuberculosisDrug-susceptible strainsDrug resistance profilesActive diseasePulmonary tuberculosisDisease progressionGuideline producersHealth centersIndex patientsEffective treatmentPatients
2011
Increasing Drug Resistance in Extensively Drug-Resistant Tuberculosis, South Africa - Volume 17, Number 3—March 2011 - Emerging Infectious Diseases journal - CDC
Shah NS, Richardson J, Moodley P, Moodley S, Babaria P, Ramtahal M, Heysell SK, Li X, Moll AP, Friedland G, Sturm AW, Gandhi NR. Increasing Drug Resistance in Extensively Drug-Resistant Tuberculosis, South Africa - Volume 17, Number 3—March 2011 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2011, 17: 510-513. PMID: 21392446, PMCID: PMC3166021, DOI: 10.3201/eid1703.101363.Peer-Reviewed Original ResearchConceptsExtensively Drug-Resistant TuberculosisTuberculosis drug susceptibility testingDrug-resistant Mycobacterium tuberculosisInfectious Diseases journal - CDCDrug-resistant TBDrug-resistant tuberculosisDrug susceptibility testingEffective treatmentAvailable drugsDrug resistanceSusceptibility testingMycobacterium tuberculosisTuberculosisDrugsPatients
2010
Extensively Drug-Resistant Mycobacterium tuberculosis from Aspirates, Rural South Africa - Volume 16, Number 3—March 2010 - Emerging Infectious Diseases journal - CDC
Heysell SK, Moll AP, Gandhi NR, Eksteen F, Babaria P, Coovadia Y, Roux L, Lalloo U, Friedland G, Shah NS, Heysell S, Moll A, Gandhi N, Eksteen F, Babaria P, Coovadia Y, Roux L, Lalloo U, Friedland G, Shah N, Heysell S, Moll A, Gandhi N, Eksteen F, Babaria P, Coovadia Y, Roux L, Lalloo U, Friedland G, Shah N. Extensively Drug-Resistant Mycobacterium tuberculosis from Aspirates, Rural South Africa - Volume 16, Number 3—March 2010 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2010, 16: 557-560. PMID: 20202446, PMCID: PMC3322040, DOI: 10.3201/eid1603.091486.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsAntitubercular AgentsBiopsy, Fine-NeedleCulture MediaDrug Resistance, Multiple, BacterialExtensively Drug-Resistant TuberculosisFemaleHIV InfectionsHumansLymph NodesMaleMicrobial Sensitivity TestsMycobacterium tuberculosisPleural EffusionRural PopulationSouth Africa
2009
Mathematical models of the epidemiology and control of drug-resistant TB
Cohen T, Dye C, Colijn C, Williams B, Murray M. Mathematical models of the epidemiology and control of drug-resistant TB. Expert Review Of Respiratory Medicine 2009, 3: 67-79. PMID: 20477283, DOI: 10.1586/17476348.3.1.67.Peer-Reviewed Original ResearchDrug-resistant TBDrug resistanceMultiple drug-resistant Mycobacterium tuberculosisDrug-resistant Mycobacterium tuberculosisDrug-resistant M. tuberculosisCombination chemotherapyTB controlM. tuberculosisMycobacterium tuberculosisAntibiotic resistanceRecent reportsTuberculosisEpidemiologyTBExtrinsic determinantsInterventionCost effectivenessReproductive capacityChemotherapyControlPrevalence
2007
Co-infection with human immunodeficiency virus and tuberculosis in Asia
Vermund SH, Yamamoto N. Co-infection with human immunodeficiency virus and tuberculosis in Asia. Tuberculosis 2007, 87: s18-s25. PMID: 17631414, PMCID: PMC2031213, DOI: 10.1016/j.tube.2007.05.008.Peer-Reviewed Original ResearchConceptsMultiple drug-resistant Mycobacterium tuberculosisDrug-resistant Mycobacterium tuberculosisCo-infected patientsHuman immunodeficiency virusDeath of HIVPublic health workersHIV-tuberculosisHIV seroprevalenceTuberculosis casesImmunodeficiency virusHealth workersTuberculosis accountsPublic health situationMarked riseMycobacterium tuberculosisKey subpopulationsHealth situationTuberculosisResearch prioritiesSalient studiesHigher numberHIVPatientsSeroprevalenceInterdisciplinary collaboration
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