2013
Control of the G- protein cascade dynamics by GDP dissociation inhibitors
Nikonova E, Tsyganov MA, Kolch W, Fey D, Kholodenko BN. Control of the G- protein cascade dynamics by GDP dissociation inhibitors. Molecular Omics 2013, 9: 2454-2462. PMID: 23872884, DOI: 10.1039/c3mb70152b.Peer-Reviewed Original ResearchConceptsGDP dissociation inhibitorGuanine nucleotide exchange factorsRho family GTPasesDissociation inhibitorNucleotide exchange factorsKey cellular processesProtrusion-retraction cyclesSignal-induced changesCell migration behaviorActive GTPExchange factorInactive GDPCellular processesGTPase activityRac1 activityGTPasesBistable switchRhoADistinct modesRhoGDI1GTPaseInhibitorsRac1GTPCytoplasm
2010
Nucleobindin 1 Is a Calcium-regulated Guanine Nucleotide Dissociation Inhibitor of Gαi1 *
Kapoor N, Gupta R, Menon ST, Folta-Stogniew E, Raleigh DP, Sakmar TP. Nucleobindin 1 Is a Calcium-regulated Guanine Nucleotide Dissociation Inhibitor of Gαi1 *. Journal Of Biological Chemistry 2010, 285: 31647-31660. PMID: 20679342, PMCID: PMC2951237, DOI: 10.1074/jbc.m110.148429.Peer-Reviewed Original ResearchConceptsNucleobindin-1Dissociation inhibitorHeterotrimeric G protein α subunitsGuanine Nucleotide Dissociation InhibitorG protein α subunitsNucleotide Dissociation InhibitorHeterotrimeric G proteinsProtein α subunitsReceptor-mediated signal transduction pathwaysSignal transduction pathwaysGoLoco motifGDI activityProtein traffickingRGS proteinsBiochemical functionsTransduction pathwaysGDP releaseΑ-subunitCalcium-binding proteinsG proteinsConformational changesBiochemical propertiesTissue culture experimentsFluorescence spectroscopy experimentsAdenylyl cyclaseThe Stress Hormone Corticosterone Increases Synaptic α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors via Serum- and Glucocorticoid-inducible Kinase (SGK) Regulation of the GDI-Rab4 Complex*
Liu W, Yuen EY, Yan Z. The Stress Hormone Corticosterone Increases Synaptic α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors via Serum- and Glucocorticoid-inducible Kinase (SGK) Regulation of the GDI-Rab4 Complex*. Journal Of Biological Chemistry 2010, 285: 6101-6108. PMID: 20051515, PMCID: PMC2825404, DOI: 10.1074/jbc.m109.050229.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Inflammatory AgentsCell LineCerebral CortexCorticosteroneGuanine Nucleotide Dissociation InhibitorsImmediate-Early ProteinsMiceNeuronsProtein Serine-Threonine KinasesProtein Transportrab4 GTP-Binding ProteinsRatsReceptors, AMPAReceptors, NeurotransmitterSynapsesUp-RegulationConceptsNucleotide Dissociation InhibitorSer-213Glucocorticoid-inducible kinaseRab proteinsKinase regulationDissociation inhibitorIsoxazolepropionic acid (AMPA) receptorsSmall GTPaseEarly endosomesAcid receptorsFunctional cycleCorticosteroid signalingSGK phosphorylationPlasma membraneRab4Receptor recyclingMolecular mechanismsCellular targetsCorticosteroid stress hormonesNeuronal functionPhosphorylationSurface expressionStress hormonesMembraneRegulation
2006
In Vivo Dynamics of Rac-Membrane Interactions
Moissoglu K, Slepchenko BM, Meller N, Horwitz AF, Schwartz MA. In Vivo Dynamics of Rac-Membrane Interactions. Molecular Biology Of The Cell 2006, 17: 2770-2779. PMID: 16597700, PMCID: PMC1474787, DOI: 10.1091/mbc.e06-01-0005.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAnimalsCell MembraneComputer SimulationDiffusionGenes, ReporterGuanine Nucleotide Dissociation InhibitorsKineticsMiceMicroscopy, ConfocalModels, TheoreticalPlasmidsProtein Transportrac GTP-Binding ProteinsRecombinant Fusion ProteinsRecombinant Proteinsrho-Specific Guanine Nucleotide Dissociation InhibitorsConceptsGuanine Nucleotide Dissociation InhibitorGTPase-activating proteinsGTP-RacNucleotide exchange factorsVivo dynamicsSmall hairpin RNADissociation inhibitorMembrane associationExchange factorRac functionGEF Tiam1Hairpin RNARhoGDIPhotobleaching methodRacCytosolOverexpressionMajor routeDissociation rate constantsTiam1RNAProteinDetectable rateMembraneActivation
2000
GDP Dissociation Inhibitor Domain II Required for Rab GTPase Recycling*
Gilbert P, Burd C. GDP Dissociation Inhibitor Domain II Required for Rab GTPase Recycling*. Journal Of Biological Chemistry 2000, 276: 8014-8020. PMID: 11116150, DOI: 10.1074/jbc.m008845200.Peer-Reviewed Original ResearchConceptsGDP dissociation inhibitorDomain IIRab GDP dissociation inhibitorRab bindingRab localizationGenetic screenRab GTPasesTransport intermediatesDissociation inhibitorDeletion strainAcceptor membranesCytosolic poolVps21pVesicle fusionRabDomain IMutantsGdi1pYpt1pGeneral defectOrganellesCytosolMembraneDistinct subsetsSec4p
1999
Molecular Dissection of Guanine Nucleotide Dissociation Inhibitor Function in Vivo Rab-INDEPENDENT BINDING TO MEMBRANES AND ROLE OF RAB RECYCLING FACTORS*
Luan P, Balch W, Emr S, Burd C. Molecular Dissection of Guanine Nucleotide Dissociation Inhibitor Function in Vivo Rab-INDEPENDENT BINDING TO MEMBRANES AND ROLE OF RAB RECYCLING FACTORS*. Journal Of Biological Chemistry 1999, 274: 14806-14817. PMID: 10329679, DOI: 10.1074/jbc.274.21.14806.Peer-Reviewed Original ResearchConceptsRecycling factorNucleotide Dissociation InhibitorFusion of vesiclesSite-directed mutagenesisAmino acid residuesRab deliveryDistinct RabsRab GTPasesRab proteinsRab-GDPDissociation inhibitorMembrane associationEssential proteinsMolecular dissectionEndocytic pathwayGDI functionAcid residuesRabCellular membranesDominant inhibitionMultiple effectorsRate of recyclingInhibitor functionProteinEndogenous poolConstitutive Calcium-independent Release of Toxoplasma gondii Dense Granules Occurs through the NSF/SNAP/SNARE/Rab Machinery*
Chaturvedi S, Qi H, Coleman D, Rodriguez A, Hanson P, Striepen B, Roos D, Joiner K. Constitutive Calcium-independent Release of Toxoplasma gondii Dense Granules Occurs through the NSF/SNAP/SNARE/Rab Machinery*. Journal Of Biological Chemistry 1999, 274: 2424-2431. PMID: 9891012, DOI: 10.1074/jbc.274.4.2424.Peer-Reviewed Original ResearchConceptsN-ethylmaleimide-sensitive fusion proteinDense matrix granulesDense granulesBeta-lactamase secretionMammalian homologueDissociation inhibitorAbsence of ATPPathogenic protozoan parasitesCalcium-independent fashionPermeabilized parasitesFusion proteinProtein componentsProtozoan parasiteCalcium-independent releaseDense granule releaseParasitesMachineryProteinN-ethylmaleimideGuanosine 5'Matrix granulesGranule releaseToxoplasma gondiiGranulesHomologues
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