Role of Tissue Macrophages in the Development of Critical Illness Diabetes
Jiang S, Gavrikova T, Sharifov O, Messina J. Role of Tissue Macrophages in the Development of Critical Illness Diabetes. Shock 2012, 37: 70-76. PMID: 21841539, PMCID: PMC3237746, DOI: 10.1097/shk.0b013e31823180a4.Peer-Reviewed Original ResearchConceptsInsulin resistanceClodronate-liposomesMacrophage depletionGadolinium chlorideHepatic insulin resistanceAdministration of gadolinium chlorideIntravenous administration of gadolinium chlorideDepletion of macrophagesMacrophage-derived factorsInitial development of insulin resistanceSpleen of ratsDevelopment of insulin resistanceMacrophage-independentHepatic Insulin SignalingInsulin-resistant statesSurgical traumaIntravenous administrationResident macrophagesTNF-aLiver of ratsHemorrhage periodSpleen macrophagesTissue macrophagesRodent modelsCritical illness
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