2018
Nonalcoholic fatty liver disease impairs expression of the type II inositol 1,4,5‐trisphosphate receptor
Khamphaya T, Chukijrungroat N, Saengsirisuwan V, Mitchell‐Richards K, Robert ME, Mennone A, Ananthanarayanan M, Nathanson MH, Weerachayaphorn J. Nonalcoholic fatty liver disease impairs expression of the type II inositol 1,4,5‐trisphosphate receptor. Hepatology 2018, 67: 560-574. PMID: 29023819, PMCID: PMC5893412, DOI: 10.1002/hep.29588.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseImpaired liver regenerationNonalcoholic steatohepatitisLiver regenerationHuh7 cellsLiver diseaseEffect of NAFLDPrevalent liver diseaseFatty liver diseaseC-JunHigh-fructose dietLiver biopsy specimensCell proliferationCalcium signalingHepG2 cellsLiver of ratsCell nuclear antigenCalcium release channelSimple steatosisLiver biopsyFatty liverTrisphosphate receptorBiopsy specimensRat modelType II inositol
2012
Role of Tissue Macrophages in the Development of Critical Illness Diabetes
Jiang S, Gavrikova T, Sharifov O, Messina J. Role of Tissue Macrophages in the Development of Critical Illness Diabetes. Shock 2012, 37: 70-76. PMID: 21841539, PMCID: PMC3237746, DOI: 10.1097/shk.0b013e31823180a4.Peer-Reviewed Original ResearchConceptsInsulin resistanceClodronate-liposomesMacrophage depletionGadolinium chlorideHepatic insulin resistanceAdministration of gadolinium chlorideIntravenous administration of gadolinium chlorideDepletion of macrophagesMacrophage-derived factorsInitial development of insulin resistanceSpleen of ratsDevelopment of insulin resistanceMacrophage-independentHepatic Insulin SignalingInsulin-resistant statesSurgical traumaIntravenous administrationResident macrophagesTNF-aLiver of ratsHemorrhage periodSpleen macrophagesTissue macrophagesRodent modelsCritical illness
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