2025
215-OR: Increased White Adipose Tissue Oxidative Capacity and Insulin Resistance Are Early Changes upon High-Fat Diet in Healthy Humans
XOURAFA G, GRANATA C, TRENKAMP S, KORZEKWA B, SCHRAUWEN-HINDERLING V, PETERSEN K, SHULMAN G, KAHL S, RODEN M. 215-OR: Increased White Adipose Tissue Oxidative Capacity and Insulin Resistance Are Early Changes upon High-Fat Diet in Healthy Humans. Diabetes 2025, 74 DOI: 10.2337/db25-215-or.Peer-Reviewed Original ResearchWhite adipose tissueFat mass indexInsulin resistanceHigh-fat dietLipid contentEuropean Association for the StudyNon-esterified fatty acidsInsulin sensitivityLiver lipid contentParallel-group studyEuropean Association for the Study of DiabetesNon-obese individualsAdipose tissue insulin resistanceWhole-body insulin sensitivityPromote insulin resistanceTissue insulin resistanceHepatic ATP levelsHigh-resolution respirometryHyperinsulinemic-euglycemic clampMitochondrial respirationStudy of DiabetesWhole-body insulin resistanceInsulin stimulationHepatic lipid contentHypercaloric high-fat diet
2024
Adipose tissue insulin resistance in children and adolescents: linking glucose and free fatty acid metabolism to hepatic injury markers
Bonet J, Weiss R, Galderisi A, Man C, Caprio S, Santoro N. Adipose tissue insulin resistance in children and adolescents: linking glucose and free fatty acid metabolism to hepatic injury markers. AJP Endocrinology And Metabolism 2024, 327: e723-e728. PMID: 39503461, PMCID: PMC11684862, DOI: 10.1152/ajpendo.00270.2024.Peer-Reviewed Original ResearchImpaired glucose toleranceInsulin sensitivity indexAlanine transaminaseInsulin resistanceFree fatty acid metabolismInsulin sensitivityP<10<sup>-6</sup>Years of follow-upMeasurement of liver function testsLiver function testsFree fatty acidsAdipose tissue insulin resistanceAdipose tissue insulin sensitivityHepatic injury markersPlasma alanine transaminaseEstimated insulin sensitivity indexTissue insulin sensitivityMann-Whitney testTissue insulin resistanceType 2 diabetesDevelopment of insulin resistanceProgression of insulin resistanceOral minimal modelCardiometabolic complicationsInsulin-resistant states
2022
Adipose Tissue Insulin Resistance Is Not Associated With Changes in the Degree of Obesity in Children and Adolescents
Halloun R, Galderisi A, Caprio S, Weiss R. Adipose Tissue Insulin Resistance Is Not Associated With Changes in the Degree of Obesity in Children and Adolescents. The Journal Of Clinical Endocrinology & Metabolism 2022, 108: 1053-1060. PMID: 36469736, PMCID: PMC10306082, DOI: 10.1210/clinem/dgac700.Peer-Reviewed Original ResearchConceptsAdipose tissue insulin resistanceDegree of obesityTissue insulin resistanceWhole-body insulin sensitivityTissue insulin sensitivityInsulin resistanceInsulin sensitivityMultivariate analysisSecondary analysisBody mass index z-scorePediatric weight management clinicOral glucose tolerance testInsulin sensitivity/resistanceSkeletal muscle insulin resistanceFree fatty acid concentrationsWeight management clinicGlucose tolerance testMain outcome measuresDevelopment of obesityIndex z-scoreCarbohydrate-insulin modelMuscle insulin resistanceSensitivity/resistanceManagement clinicTolerance test
2021
Elevated circulating follistatin associates with an increased risk of type 2 diabetes
Wu C, Borné Y, Gao R, López Rodriguez M, Roell W, Wilson J, Regmi A, Luan C, Aly D, Peter A, Machann J, Staiger H, Fritsche A, Birkenfeld A, Tao R, Wagner R, Canouil M, Hong M, Schwenk J, Ahlqvist E, Kaikkonen M, Nilsson P, Shore A, Khan F, Natali A, Melander O, Orho-Melander M, Nilsson J, Häring H, Renström E, Wollheim C, Engström G, Weng J, Pearson E, Franks P, White M, Duffin K, Vaag A, Laakso M, Stefan N, Groop L, De Marinis Y. Elevated circulating follistatin associates with an increased risk of type 2 diabetes. Nature Communications 2021, 12: 6486. PMID: 34759311, PMCID: PMC8580990, DOI: 10.1038/s41467-021-26536-w.Peer-Reviewed Original ResearchConceptsAdipose tissue insulin resistanceTissue insulin resistanceType 2 diabetesFollistatin levelsGlucokinase regulatory protein geneFollistatin secretionHazard ratioInsulin resistanceNon-alcoholic fatty liver diseaseAdjusted hazard ratioFatty liver diseaseRisk of T2DFree fatty acid releaseFatty acid releaseIncident T2DLiver diseaseGenome-wide association studiesHuman adipocytesT2DAcid releaseStandard deviation increaseDiabetesSecretionRiskRegulatory protein geneShort-term overnutrition induces white adipose tissue insulin resistance through sn-1,2-diacylglycerol – PKCε – insulin receptorT1160 phosphorylation
Lyu K, Zhang D, Song J, Li X, Perry RJ, Samuel VT, Shulman GI. Short-term overnutrition induces white adipose tissue insulin resistance through sn-1,2-diacylglycerol – PKCε – insulin receptorT1160 phosphorylation. JCI Insight 2021, 6: e139946. PMID: 33411692, PMCID: PMC7934919, DOI: 10.1172/jci.insight.139946.Peer-Reviewed Original ResearchConceptsInsulin resistanceInsulin actionAdipose tissue insulin resistanceTissue insulin resistanceWT control miceHyperinsulinemic-euglycemic clampShort-term HFDTissue insulin actionAdipose tissue insulin actionDiet-fed ratsPotential therapeutic targetHFD feedingControl miceInsulin sensitivityTherapeutic targetLipolysis suppressionImpairs insulinHFDPKCε activationGlucose uptakeΕ activationMiceDiacylglycerol accumulationRecent evidenceProtein kinase C
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply