2024
Secure discovery of genetic relatives across large-scale and distributed genomic datasets
Hong M, Froelicher D, Magner R, Popic V, Berger B, Cho H. Secure discovery of genetic relatives across large-scale and distributed genomic datasets. Genome Research 2024, 34: gr.279057.124. PMID: 39111815, PMCID: PMC11529841, DOI: 10.1101/gr.279057.124.Peer-Reviewed Original ResearchMultiparty homomorphic encryptionIdentity-by-descentEffective hash functionsGenomic datasetsHomomorphic encryptionHash functionPrivate dataFederated algorithmBucketing strategyData holdersData silosDegree of relatednessRelation detectionGenetic relationEfficient algorithmMultiple entitiesRelatedness coefficientsPairs of individualsGenomic studiesDatasetIdentification of relationsRuntimeGenetic sequencesAccurate detectionAlgorithm
2019
Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches
Yao S, Kuja-Halkola R, Martin J, Lu Y, Lichtenstein P, Norring C, Birgegård A, Yilmaz Z, Hübel C, Watson H, Baker J, Almqvist C, Consortium E, Adan R, Ando T, Baker J, Bergen A, Berrettini W, Birgegård A, Boni C, Perica V, Brandt H, Burghardt R, Cassina M, Cesta C, Clementi M, Coleman J, Cone R, Courtet P, Crawford S, Crow S, Crowley J, Danner U, Davis O, de Zwaan M, Dedoussis G, Degortes D, DeSocio J, Dick D, Dikeos D, Dmitrzak-Weglarz M, Docampo E, Egberts K, Ehrlich S, Escaramís G, Esko T, Estivill X, Favaro A, Fernández-Aranda F, Fichter M, Finan C, Fischer K, Föcker M, Foretova L, Forzan M, Franklin C, Gaspar H, Gonidakis F, Gorwood P, Gratacos M, Guillaume S, Guo Y, Hakonarson H, Halmi K, Hatzikotoulas K, Hauser J, Hebebrand J, Helder S, Hendriks J, Herpertz-Dahlmann B, Herzog W, Hilliard C, Hinney A, Huckins L, Hudson J, Huemer J, Imgart H, Inoko H, Jiménez-Murcia S, Johnson C, Jordan J, Juréus A, Kalsi G, Kaminska D, Kaplan A, Kaprio J, Karhunen L, Karwautz A, Kas M, Kaye W, Kennedy J, Kennedy M, Keski-Rahkonen A, Kiezebrink K, Kim Y, Klump K, Knudsen G, Koeleman B, Koubek D, La Via M, Landén M, Levitan R, Li D, Lichtenstein P, Lilenfeld L, Lissowska J, Magistretti P, Maj M, Mannik K, Martin N, McDevitt S, McGuffin P, Merl E, Metspalu A, Meulenbelt I, Micali N, Mitchell J, Mitchell K, Monteleone P, Monteleone A, Mortensen P, Munn-Chernoff M, Nacmias B, Nilsson I, Norring C, Ntalla I, O’Toole J, Pantel J, Papezova H, Parker R, Rabionet R, Raevuori A, Rajewski A, Ramoz N, Rayner N, Reichborn-Kjennerud T, Ricca V, Ripke S, Ritschel F, Roberts M, Rotondo A, Rybakowski F, Santonastaso P, Scherag A, Schmidt U, Schork N, Schosser A, Seitz J, Slachtova L, Slagboom P, Landt M, Slopien A, Smith T, Sorbi S, Strengman E, Strober M, Sullivan P, Szatkiewicz J, Szeszenia-Dabrowska N, Tachmazidou I, Tenconi E, Thornton L, Tortorella A, Tozzi F, Treasure J, Tsitsika A, Tziouvas K, van Elburg A, van Furth E, Wade T, Wagner G, Walton E, Watson H, Woodside D, Yao S, Yilmaz Z, Zeggini E, Zerwas S, Zipfel S, Alfredsson L, Andreassen O, Aschauer H, Barrett J, Bencko V, Carlberg L, Cichon S, Cohen-Woods S, Dina C, Ding B, Espeseth T, Floyd J, Gallinger S, Gambaro G, Giegling I, Herms S, Janout V, Julià A, Klareskog L, Le Hellard S, Leboyer M, Lundervold A, Marsal S, Mattingsdal M, Navratilova M, Ophoff R, Palotie A, Pinto D, Ripatti S, Rujescu D, Scherer S, Scott L, Sladek R, Soranzo N, Southam L, Steen V, Wichmann H, Widen E, Breen G, Bulik C, Thornton L, Magnusson P, Bulik C, Larsson H. Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches. Biological Psychiatry 2019, 86: 577-586. PMID: 31301758, PMCID: PMC6776821, DOI: 10.1016/j.biopsych.2019.04.036.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresAttention-deficit/hyperactivity disorder polygenic risk scoresAttention-deficit/hyperactivity disorderQuantitative genetic modelRisk scoreGenetic associationGenetic correlationsEating DisordersRegister-based informationAnorexia nervosaPopulation-based sampleGenetic modelsDegree of relatednessGenetically informed approachesAttention-deficit/hyperactivityNationwide population studyMaternal half-sistersCorrelates of attention-deficit/hyperactivity disorderFull-sistersAttention-deficit/hyperactivity disorder symptomsFamilial coaggregationNationwide PopulationGenetically informative designsShared etiologySubscales Drive
1993
Rates of DNA evolution in Drosophila depend on function and developmental stage of expression.
Powell J, Caccone A, Gleason J, Nigro L. Rates of DNA evolution in Drosophila depend on function and developmental stage of expression. Genetics 1993, 133: 291-298. PMID: 8094697, PMCID: PMC1205319, DOI: 10.1093/genetics/133.2.291.Peer-Reviewed Original ResearchConceptsComplementary DNADNA-DNA hybridization experimentsTotal single-copy DNALineage-specific shiftsSingle-copy genomeDivergence of genesSpecies of DrosophilaDevelopmental stagesDNA sequence divergenceGreater evolutionary distanceSingle-copy DNADifferent developmental stagesDNA evolutionEvolutionary distanceCodon usageCDNA sequenceSequence dataHybridization experimentsDegree of relatednessDrosophilaEmbryonic stagesSilent substitutionsGenesSpeciesDNA
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