2022
PLD3 affects axonal spheroids and network defects in Alzheimer’s disease
Yuan P, Zhang M, Tong L, Morse T, McDougal R, Ding H, Chan D, Cai Y, Grutzendler J. PLD3 affects axonal spheroids and network defects in Alzheimer’s disease. Nature 2022, 612: 328-337. PMID: 36450991, PMCID: PMC9729106, DOI: 10.1038/s41586-022-05491-6.Peer-Reviewed Original ResearchConceptsAxonal spheroidsAlzheimer's diseaseConduction blockadeNeural circuit abnormalitiesNeural network dysfunctionAmyloid removalCircuit abnormalitiesAge-dependent accumulationNetwork dysfunctionEndolysosomal vesiclesMouse modelNeuronal overexpressionCognitive declineAxonal connectivityDiseasePrecise mechanismBlockadePLD3Neural network functionSpheroid growthSevere disruptionCurrent sinkVoltage imagingSize-dependent mannerDysfunction
2011
Determination of Cortical Circuit Function Using Current Source-Density Analysis In Vivo
Higley M. Determination of Cortical Circuit Function Using Current Source-Density Analysis In Vivo. Neuromethods 2011, 67: 205-218. DOI: 10.1007/7657_2011_6.Peer-Reviewed Original ResearchCurrent source density analysisLocal field potentialsSource density analysisCortical circuit functionPathological activity patternsSmall neuronal populationsExtracellular current sinksRodent neocortexSynaptic activityRelative technical easeNeuronal populationsCognitive functionNeural synaptic activityCortical networksTechnical easeMotor planningField potentialsCircuit functionCSD analysisFunctional mapsSensory encodingActivity patternsVivoCurrent sinkLFP signals
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