2023
Sputum Microbiome and Chronic Obstructive Pulmonary Disease in a Rural Ugandan Cohort of Well-Controlled HIV Infection
Kayongo A, Bartolomaeus T, Birkner T, Markó L, Löber U, Kigozi E, Atugonza C, Munana R, Mawanda D, Sekibira R, Uwimaana E, Alupo P, Kalyesubula R, Knauf F, Siddharthan T, Bagaya B, Kateete D, Joloba M, Sewankambo N, Jjingo D, Kirenga B, Checkley W, Forslund S. Sputum Microbiome and Chronic Obstructive Pulmonary Disease in a Rural Ugandan Cohort of Well-Controlled HIV Infection. Microbiology Spectrum 2023, 11: e02139-21. PMID: 36790203, PMCID: PMC10100697, DOI: 10.1128/spectrum.02139-21.Peer-Reviewed Original ResearchChronic obstructive pulmonary diseaseObstructive pulmonary diseaseAntiretroviral therapySputum microbiomeHIV cohortPulmonary diseaseSputum microbiotaRespiratory microbiotaStable chronic obstructive pulmonary diseaseLower respiratory tract microbiotaNoninfectious lung diseasePost-ART initiationRural UgandaRural Ugandan cohortHIV-positive patientsChronic lung inflammationRisk stratification strategiesCross-sectional studyRespiratory tract microbiotaHIV/AIDSCOPD statusHIV suppressionCOPD severityViral suppressionLung inflammation
2018
A functional macrophage migration inhibitory factor promoter polymorphism is associated with reduced diffusing capacity
Zhang C, Ramsey C, Berical A, Yu L, Leng L, McGinnis K, Song Y, Michael H, McCormack M, Allore H, Morris A, Crothers K, Bucala R, Lee P, Sauler M. A functional macrophage migration inhibitory factor promoter polymorphism is associated with reduced diffusing capacity. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2018, 316: l400-l405. PMID: 30520689, PMCID: PMC6397351, DOI: 10.1152/ajplung.00439.2018.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorChronic obstructive pulmonary diseaseMIF -794 CATTAbnormal diffusion capacityCigarette smoke exposureSmoke exposureAssociation of MIFDiffusion capacityMacrophage migration inhibitory factor (MIF) promoter polymorphismsPathogenesis of COPDChronic cigarette smoke exposureMultivariable logistic regression modelModifiable risk factorsObstructive pulmonary diseaseMigration inhibitory factorCross-sectional analysisLogistic regression modelsCommon genetic polymorphismsInnate immune genesAirflow obstructionMIF expressionCOPD severityPulmonary diseaseMIF allelesRisk factorsThe DNA repair transcriptome in severe COPD
Sauler M, Lamontagne M, Finnemore E, Herazo-Maya JD, Tedrow J, Zhang X, Morneau JE, Sciurba F, Timens W, Paré PD, Lee PJ, Kaminski N, Bossé Y, Gomez JL. The DNA repair transcriptome in severe COPD. European Respiratory Journal 2018, 52: 1701994. PMID: 30190272, PMCID: PMC6422831, DOI: 10.1183/13993003.01994-2017.Peer-Reviewed Original ResearchConceptsDNA damage toleranceDNA repairInadequate DNA repairSevere chronic obstructive pulmonary diseaseChronic obstructive pulmonary diseaseRepair pathwaysGene correlation network analysisIntegrative genomics approachNucleotide excision repair pathwayDNA repair pathwaysGene Set Enrichment AnalysisExcision repair pathwayGlobal transcriptomic profilesDNA repair genesDNA repair responseCorrelation network analysisCOPD severityGenomic approachesLung tissue transcriptomeTranscriptomic differencesTranscriptomic changesTranscriptomic patternsRNA sequencingTissue transcriptomesTranscriptomic profilesHypercapnia increases airway smooth muscle contractility via caspase-7–mediated miR-133a–RhoA signaling
Shigemura M, Lecuona E, Angulo M, Homma T, Rodríguez DA, Gonzalez-Gonzalez FJ, Welch LC, Amarelle L, Kim SJ, Kaminski N, Budinger GRS, Solway J, Sznajder JI. Hypercapnia increases airway smooth muscle contractility via caspase-7–mediated miR-133a–RhoA signaling. Science Translational Medicine 2018, 10 PMID: 30185650, PMCID: PMC6889079, DOI: 10.1126/scitranslmed.aat1662.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAgedAged, 80 and overAirway ResistanceAnimalsCalciumCalpainCarbon DioxideCaspase 7Chronic DiseaseDown-RegulationEnzyme ActivationFemaleHumansHypercapniaMaleMEF2 Transcription FactorsMice, Inbred C57BLMicroRNAsMiddle AgedMuscle ContractionMuscle, SmoothMyocytes, Smooth MusclePulmonary Disease, Chronic ObstructiverhoA GTP-Binding ProteinSignal TransductionConceptsChronic obstructive pulmonary diseaseAirway smooth muscle cellsSmooth muscle cellsMouse airway smooth muscle cellsSevere chronic obstructive pulmonary diseaseHuman airway smooth muscle cellsAirway smooth muscle contractilityMuscle cellsCorrection of hypercapniaSmooth muscle cell contractionCohort of patientsObstructive pulmonary diseaseHigh airway resistanceSevere lung diseaseDevelopment of hypercapniaSmooth muscle contractilityMuscle cell contractionRas homolog family member AMyosin light chain phosphorylationAirway contractilityAirway contractionHypercapnic patientsCOPD severityPulmonary diseaseAirway resistance
2015
Effects of One-Hour Training Course and Spirometry on the Ability of Physicians to Diagnose and Treat Chronic Obstructive Pulmonary Disease
Cai S, Qin L, Tanoue L, Hu A, Jia X, Luo H, Chen Y, Chen P, Peng H. Effects of One-Hour Training Course and Spirometry on the Ability of Physicians to Diagnose and Treat Chronic Obstructive Pulmonary Disease. PLOS ONE 2015, 10: e0117348. PMID: 25706774, PMCID: PMC4338104, DOI: 10.1371/journal.pone.0117348.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseAbility of physiciansSpirometric dataPulmonary diseasePresence of COPDPrevalence of COPDSeverity of COPDPatient subjectsPersons 40 yearsMean correct scoreTraining sessionsCOPD guidelinesCOPD severityPhysician visitsSpirometry resultsPhysician subjectsSecondary hospitalsSpirometric resultsPhysicians' knowledgeSpirometryPhysician responsesPhysiciansPatientsHospital
2013
Advances in the Outpatient Management of Chronic Obstructive Pulmonary Disease
Possick J, Most J, Rochester C. Advances in the Outpatient Management of Chronic Obstructive Pulmonary Disease. Clinical Pulmonary Medicine 2013, 20: 259-270. DOI: 10.1097/cpm.0000000000000001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseSymptom burdenPulmonary diseasePatient assessmentFunctional limitationsManifestations of COPDRecognition of COPDUnderstanding of COPDPhenotype-specific treatmentsCharacterization of patientsCurrent management guidelinesCost of careForm of therapyExacerbation frequencyExacerbation riskAirflow obstructionCOPD careCOPD severityCOPD managementGOLD guidelinesIntractable symptomsOutpatient managementOutpatient settingHeterogenous disease
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