2021
Clinical Presentation, Investigation and Control of an Outbreak of Adenoviral Conjunctivitis in a Neonatal Unit at a Tertiary Hospital
Thakur A, Goyal K, Chauhan P, Sharma B, Dhir S, Katoch D, Biswal M, Talati S, Bhogal R, Mohan L, Sapra M, Gupta A, Sundaram V, Dutta S, Kumar P, Singh M. Clinical Presentation, Investigation and Control of an Outbreak of Adenoviral Conjunctivitis in a Neonatal Unit at a Tertiary Hospital. The Pediatric Infectious Disease Journal 2021, 41: 243-247. PMID: 35144268, DOI: 10.1097/inf.0000000000003347.Peer-Reviewed Original ResearchConceptsROP screeningAdenoviral conjunctivitisEye dropsNosocomial spreadPolymerase chain reactionTopical steroid eye dropsAdenovirus infectionAdenoviral outbreakSteroid eye dropsNeonatal care unitTobramycin eye dropsEpidemiological outbreak investigationROP examinationsInfected babiesLid edemaAdenovirus conjunctivitisInfected neonatesNeonatal unitClinical presentationNeonatal nurseryClinical featuresClinical manifestationsDisease courseNeonatesCare unitTransplant Adenovirus Infection: Clinical Syndromes, Diagnosis, and Management
Malinis M, Azar M. Transplant Adenovirus Infection: Clinical Syndromes, Diagnosis, and Management. 2021, 781-805. DOI: 10.1007/978-3-030-25869-6_33.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSolid organ transplant recipientsInadequate clinical responseReduction of immunosuppressionCornerstone of treatmentOrgan transplant recipientsSolid organ transplantationManifestations of diseaseDirect antigen detectionGraft dysfunctionGraft lossImmunosuppression reductionTransplant recipientsClinical responseAntiviral therapySignificant morbidityAsymptomatic sheddingTherapeutic optionsViral cultureClinical syndromeAdenoviral diseaseOrgan transplantationHematopoietic stem cellsAntigen detectionAdenovirus infectionInfection
2020
Brincidofovir for the treatment of human adenovirus infection in pediatric solid organ transplant recipients: A case series
Londeree J, Winterberg PD, Garro R, George RP, Shin S, Liverman R, Serluco A, Romero R, Yildirim I. Brincidofovir for the treatment of human adenovirus infection in pediatric solid organ transplant recipients: A case series. Pediatric Transplantation 2020, 24: e13769. PMID: 32558134, DOI: 10.1111/petr.13769.Peer-Reviewed Original ResearchConceptsPediatric SOT recipientsSOT recipientsCase seriesSevere diseasePediatric solid organ transplant recipientsSolid organ transplant recipientsType of allograftMainstay of treatmentOrgan transplant recipientsSeverity of diseaseHuman adenovirus infectionHAdV diseaseHAdV viremiaPediatric recipientsTransplant recipientsHAdV infectionDisease courseAntiviral therapySignificant morbidityDisease presentationUS FDAAdenovirus infectionBrincidofovirDiseaseRecipientsTransplant Adenovirus Infection: Clinical Syndromes, Diagnosis, and Management
Malinis M, Azar M. Transplant Adenovirus Infection: Clinical Syndromes, Diagnosis, and Management. 2020, 1-25. DOI: 10.1007/978-3-030-01751-4_33-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSolid organ transplant recipientsInadequate clinical responseReduction of immunosuppressionCornerstone of treatmentOrgan transplant recipientsSolid organ transplantationManifestations of diseaseDirect antigen detectionGraft dysfunctionGraft lossImmunosuppression reductionTransplant recipientsClinical responseAntiviral therapySignificant morbidityAsymptomatic sheddingTherapeutic optionsViral cultureClinical syndromeAdenoviral diseaseOrgan transplantationHematopoietic stem cellsAntigen detectionAdenovirus infectionInfection
2007
Genotype Prevalence and Risk Factors for Severe Clinical Adenovirus Infection, United States 2004–2006
Gray GC, McCarthy T, Lebeck MG, Schnurr DP, Russell KL, Kajon AE, Landry ML, Leland DS, Storch GA, Ginocchio CC, Robinson CC, Demmler GJ, Saubolle MA, Kehl SC, Selvarangan R, Miller MB, Chappell JD, Zerr DM, Kiska DL, Halstead DC, Capuano AW, Setterquist SF, Chorazy ML, Dawson JD, Erdman DD. Genotype Prevalence and Risk Factors for Severe Clinical Adenovirus Infection, United States 2004–2006. Clinical Infectious Diseases 2007, 45: 1120-1131. PMID: 17918073, PMCID: PMC2064001, DOI: 10.1086/522188.Peer-Reviewed Original ResearchConceptsAdenovirus infectionIntensive care unit staySolid organ transplantationChronic disease conditionsAdenovirus isolatesUnited States 2004Adenovirus-positive specimensRisk factor modelingTyping methodsUnit stayRisk factorsAntigenic presentationChronic diseasesGenotype prevalenceClinical dataOrgan transplantationSevere diseaseRecent transplantationBone marrowBlinded comparisonDisease severityMilitary traineesSequence typing methodInfectionCancer diagnosis
1989
Evaluation of immunofluorescent reagents, centrifugation, and conventional cultures for the diagnosis of adenovirus infection
Mahafzah A, Landry M. Evaluation of immunofluorescent reagents, centrifugation, and conventional cultures for the diagnosis of adenovirus infection. Diagnostic Microbiology And Infectious Disease 1989, 12: 407-411. PMID: 2558834, DOI: 10.1016/0732-8893(89)90111-9.Peer-Reviewed Original ResearchConceptsIdentification of adenovirusCentrifugation cultureA549 cellsConventional cultureIsolation of adenovirusA549 cell monolayersMRC-5 cellsAdenovirus infectionRapid diagnosisMonoclonal antibodiesGroup-reactive antigenCell monolayersFluorescent-antibody reagentsAdenovirusAntibody reagentsDiagnosisDaysCellsImmunofluorescent reagentsHEKAdenovirus Inversely Modulates Target Cell Class I Antigen Expression and Sensitivity to Natural Killing
Storkus W, Cresswell P, Patterson E, Dawson J. Adenovirus Inversely Modulates Target Cell Class I Antigen Expression and Sensitivity to Natural Killing. 1989, 152-155. DOI: 10.1007/978-3-662-39946-0_40.Peer-Reviewed Original ResearchAntibody-dependent cellular cytotoxicityComplement-mediated cytolysisNatural killingClass INatural killer cell-mediated cytolysisMajor histocompatibility complex restrictionNK effector cellsI Antigen ExpressionCell-mediated cytolysisMHC class INK sensitiveNK cellsEffector cellsAntigen expressionCellular cytotoxicityViral specificityAdenovirus infectionTarget cellsComplex restrictionCell sensitivityNKRecent evidenceCytolysisCellsKilling
1987
Disseminated adenovirus infection in an immunocompromised host Pitfalls in diagnosis
Landry M, Fong C, Neddermann K, Solomon L, Hsiung GD. Disseminated adenovirus infection in an immunocompromised host Pitfalls in diagnosis. The American Journal Of Medicine 1987, 83: 555-559. PMID: 2821806, DOI: 10.1016/0002-9343(87)90770-4.Peer-Reviewed Original ResearchConceptsBone marrow transplant recipientsAdenovirus infectionPostmortem serum samplesDisseminated adenovirus infectionMarrow transplant recipientsMicroscopic examinationSmall bowel tissueSpecific viral diagnosisLight microscopic examinationOral ulcerationTransplant recipientsCytomegalovirus infectionLaboratory featuresComplement fixation testIll patientsBowel tissueElectron microscopic examinationDiagnostic pitfallsType 2Fatal gastroenteritisLiver tissueIntranuclear inclusionsViral diagnosisSerum samplesColon contents
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