2025
Type I interferons induce guanylate-binding proteins and lysosomal defense in hepatocytes to control malaria
Marques-da-Silva C, Schmidt-Silva C, Bowers C, Charles-Chess N, Samuel C, Shiau J, Park E, Yuan Z, Kim B, Kyle D, Harty J, MacMicking J, Kurup S. Type I interferons induce guanylate-binding proteins and lysosomal defense in hepatocytes to control malaria. Cell Host & Microbe 2025, 33: 529-544.e9. PMID: 40168996, DOI: 10.1016/j.chom.2025.03.008.Peer-Reviewed Original ResearchConceptsGuanylate-binding proteinsType I interferonPlasmodium infectionI interferonParasitophorous vacuoleLiver-stage malariaNon-immune cellsInfected host cellsCaspase-1 inflammasomeNADPH oxidase 2Clinical malariaControl malariaLysosomal fusionAntimicrobial programPlasmodium parasitesHost cellsInfected erythrocytesProtective immunityMalariaPlasmodiumGenetic inhibitionCaspase-1Immunization programsImmune circuitsMouse hepatocytes
2010
Innate Immunity to Viruses
Iwasaki A. Innate Immunity to Viruses. 2010, 183-196. DOI: 10.1128/9781555816872.ch15.Peer-Reviewed Original ResearchDNA virusesEndosomal trafficking eventsHost cell machineryMechanism of RNAiAbsence of VpuInnate immunityTrafficking eventsEndonuclease familyCell machineryCytoplasmic DNAE3 ubiquitinLipid raftsCaspase-1 inflammasomeAnalysis of animalCell surfaceViral dsRNADistinct rolesNeighboring cellsAntiviral stateBillions of yearsLike receptorsI IFN productionComplementary sequencesViral RNARNA
2009
The Caspase 1 Inflammasome Is Not Required for Control of Murine Lyme Borreliosis
Liu N, Belperron AA, Booth CJ, Bockenstedt LK. The Caspase 1 Inflammasome Is Not Required for Control of Murine Lyme Borreliosis. Infection And Immunity 2009, 77: 3320-3327. PMID: 19487481, PMCID: PMC2715671, DOI: 10.1128/iai.00100-09.Peer-Reviewed Original ResearchConceptsCaspase-1 inflammasomeCaspase-1Immune responseHost defenseLyme borreliosisToll-like receptor-mediated responsesDay 14 postinfectionPrevalence of arthritisT cell responsesApoptosis-associated speck-like proteinMild transient elevationBorrelia burgdorferiMurine Lyme borreliosisReceptor-mediated responsesCaspase-1 deficiencyC-terminal caspase recruitment domainSpeck-like proteinAbility of macrophagesEnzyme caspase-1IL-18Humoral immunityInterleukin-1betaTransient elevationPathogen burdenInflammasome
2006
Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis
Lara-Tejero M, Sutterwala FS, Ogura Y, Grant EP, Bertin J, Coyle AJ, Flavell RA, Galán J. Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. Journal Of Experimental Medicine 2006, 203: 1407-1412. PMID: 16717117, PMCID: PMC2118315, DOI: 10.1084/jem.20060206.Peer-Reviewed Original Research
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