2015
Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor
Iwata M, Ota KT, Li XY, Sakaue F, Li N, Dutheil S, Banasr M, Duric V, Yamanashi T, Kaneko K, Rasmussen K, Glasebrook A, Koester A, Song D, Jones KA, Zorn S, Smagin G, Duman RS. Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor. Biological Psychiatry 2015, 80: 12-22. PMID: 26831917, DOI: 10.1016/j.biopsych.2015.11.026.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnhedoniaAnimalsAnxietyBehavior, AnimalDepressionDisease Models, AnimalInflammasomesInterleukin-1betaMaleMiceMice, KnockoutNLR Family, Pyrin Domain-Containing 3 ProteinPurinergic P2Y Receptor AgonistsPurinergic P2Y Receptor AntagonistsRatsRats, Sprague-DawleyReceptors, Purinergic P2Y2Stress, PsychologicalTumor Necrosis Factor-alphaConceptsTumor necrosis factor alphaAcute restraint stressNecrosis factor alphaIL-1βRestraint stressFactor alphaExtracellular adenosine triphosphateAntagonist administrationDepressive behaviorNLRP3 inflammasomeChronic unpredictable stress exposureInflammatory cytokines IL-1βStress-related mood disordersStress-induced cytokineChronic unpredictable stressStress-induced inflammationCytokines IL-1βAdenosine triphosphateMajor depressive disorderNovel therapeutic targetInnate immune systemWestern blot analysisComorbid illnessesP2X7R antagonistsInflammasome cascade
2006
The effects of sex and hormonal status on restraint-stress-induced working memory impairment
Shansky RM, Rubinow K, Brennan A, Arnsten A. The effects of sex and hormonal status on restraint-stress-induced working memory impairment. Behavioral And Brain Functions 2006, 2: 8. PMID: 16522198, PMCID: PMC1420310, DOI: 10.1186/1744-9081-2-8.Peer-Reviewed Original ResearchRestraint stressStress-related disordersPrefrontal cortexFemale ratsHormonal statusCognitive functionPFC cognitive functionAcute restraint stressHigh estrogen levelsMajor depressive disorderMinutes of restraintMethodsThe present studyDendritic remodelingEstrogen levelsDepressive disorderMale ratsPharmacological stressorHormonal influencesMemory impairmentHippocampal functionSignificant impairmentNeuronal morphologyConclusionThese resultsEstrus phaseOestrous cycle
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