2020
Assessment of population-based input functions for Patlak imaging of whole body dynamic 18F-FDG PET
Naganawa M, Gallezot JD, Shah V, Mulnix T, Young C, Dias M, Chen MK, Smith AM, Carson RE. Assessment of population-based input functions for Patlak imaging of whole body dynamic 18F-FDG PET. EJNMMI Physics 2020, 7: 67. PMID: 33226522, PMCID: PMC7683759, DOI: 10.1186/s40658-020-00330-x.Peer-Reviewed Original ResearchPopulation-based input functionImage-derived input functionInitial distribution volumeArterial input functionInjected doseBlood samplingWhole bodyStandard arterial input functionInitial plasma concentrationsArterial blood samplingOncological patientsPlasma concentrationsGold standard methodDistribution volumePET studiesPET imagingSubject heightInput functionAUCAUC valuesTest-retest dataClinical environmentLater time windowKi valuesImaging
2007
Characterization and Optimization of Selective, Nonpeptidic Inhibitors of Cathepsin S with an Unprecedented Binding Mode †
Inagaki H, Tsuruoka H, Hornsby M, Lesley SA, Spraggon G, Ellman JA. Characterization and Optimization of Selective, Nonpeptidic Inhibitors of Cathepsin S with an Unprecedented Binding Mode †. Journal Of Medicinal Chemistry 2007, 50: 2693-2699. PMID: 17469812, DOI: 10.1021/jm070111+.Peer-Reviewed Original ResearchConceptsUnprecedented binding modePotent cathepsin S inhibitorsBinding modesX-ray structureLow molecular weightCathepsin S inhibitorsNonpeptidic inhibitorsK. CharacterizationMolecular weightS inhibitorsAldehyde inhibitorsFragment identificationCleavage efficiencyCathepsin SInhibitor 2SubstrateSelectivityScreening methodStructureKi valuesComplexesCathepsin BConversionCharacterizationSelective
1998
Properties of Alpha-1-Adrenergic Receptors in the Rat Prostate: Effect of Experimental Diabetes
Nishi K, Wada Y, Saito M, Foster H, Weiss R, Latifpour J. Properties of Alpha-1-Adrenergic Receptors in the Rat Prostate: Effect of Experimental Diabetes. Urologia Internationalis 1998, 61: 147-153. PMID: 9933834, DOI: 10.1159/000030311.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-AntagonistsAnalysis of VarianceAnimalsBinding SitesCulture TechniquesDiabetes Mellitus, ExperimentalDisease Models, AnimalDown-RegulationLinear ModelsMaleProstateRatsRats, Sprague-DawleyReceptors, Adrenergic, alphaReference ValuesSpleenStreptozocinSubmandibular GlandVas DeferensConceptsRat prostateAlpha-1 adrenergic receptorsInduction of diabetesSTZ-induced diabetesWeeks of streptozotocinDiabetic rat prostateSimilar pharmacological profileReceptor subtype specificityExperimental diabetesAlpha1A-subtypeRat submaxillary glandReceptor-binding experimentsRat vasPharmacological profileDiabetesProstateSubtype specificityPharmacological propertiesKi valuesSubmaxillary glandRat spleenPrazosinWB4101BMY7378Spiperone
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply