2023
Stem-like CD4 T differentiation controls CD8 T cell immunity or tolerance in cancer
Cardenas M, Prokhnevska N, Jansen C, Sobierajska E, Master V, Kissick H. Stem-like CD4 T differentiation controls CD8 T cell immunity or tolerance in cancer. The Journal Of Immunology 2023, 210: 86.04-86.04. DOI: 10.4049/jimmunol.210.supp.86.04.Peer-Reviewed Original ResearchTumor-draining lymph nodesAnti-tumor responsesCD4 T cellsEffector differentiationT cellsT-cell anti-tumor responseTumor-specific CD4 T cellsCD8 T cell responsesCD8 T cell immunityT cell effector differentiationCD4 T cell differentiationReduced tumor burdenT cell responsesT cell immunityDraining Lymph NodesT cell differentiationStem-like propertiesExpression of TCF1Tumor responseTumor burdenTreg differentiationLymph nodesCancer responseCD4 differentiationCD8SEACells infers transcriptional and epigenomic cellular states from single-cell genomics data
Persad S, Choo Z, Dien C, Sohail N, Masilionis I, Chaligné R, Nawy T, Brown C, Sharma R, Pe’er I, Setty M, Pe’er D. SEACells infers transcriptional and epigenomic cellular states from single-cell genomics data. Nature Biotechnology 2023, 41: 1746-1757. PMID: 36973557, PMCID: PMC10713451, DOI: 10.1038/s41587-023-01716-9.Peer-Reviewed Original ResearchConceptsCell statesTransposase-accessible chromatinSingle-cell sequencing dataSingle-cell dataDiscrete cell typesChromatin landscapeSequence dataGenomic dataExpression dynamicsAssociated with disease onsetCritical regulatorsGene scoreT cell differentiationCD4 T cell differentiationCell typesHematopoietic differentiationMetaCellChromatinCell clustersActive stateDifferentiationATACGenomeCellsRNA
2021
Behind the scenes with basophils: an emerging therapeutic target
Shah H, Eisenbarth S, Tormey CA, Siddon AJ. Behind the scenes with basophils: an emerging therapeutic target. Immunotherapy Advances 2021, 1: ltab008. PMID: 35919744, PMCID: PMC9327101, DOI: 10.1093/immadv/ltab008.Peer-Reviewed Original ResearchChronic myeloid leukemiaImmunoregulatory functionsMyeloproliferative neoplasmsType 2 cytokinesCD4 T cell differentiationDevelopment of immunotherapyNon-malignant diseasesT cell differentiationB cell activationBasophil biologyMalignant disease statesAllergic inflammationInflammatory mediatorsBasophil degranulationPeripheral bloodAllergic responsesIL-4Th2 cellsAberrant immunophenotypeMyeloid leukemiaAdaptive immunityHematological malignanciesMast cellsMyeloid neoplasmsDiagnostic criteria
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