2025
BK channels mediate a presynaptic form of mGluR-LTD in the neonatal hippocampus
Ancatén-González C, Meza R, Gonzalez-Sanabria N, Segura I, Alcaino A, Peña-Pichicoi A, Latorre R, Chiu C, Chávez A. BK channels mediate a presynaptic form of mGluR-LTD in the neonatal hippocampus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2411506122. PMID: 39773031, PMCID: PMC11745352, DOI: 10.1073/pnas.2411506122.Peer-Reviewed Original ResearchConceptsBK channelsLong-term depressionMGluR-LTDNeonatal hippocampusPostsynaptic metabotropic glutamate receptorsActivation of BK channelsChannel open probabilityCA3-CA1 synapsesMetabotropic glutamate receptorsArachidonic acid metabolitesRegulating synaptic strengthActivity-dependent changesOpen probabilityHippocampal slicesCircuit maturationCA3-CA1Glutamate receptorsElectrophysiological propertiesPresynaptic formP7-P10Synaptic strengthAcid metabolitesCentral synapsesNeuronal functionSynaptic function
2023
Activity-Dependent Transcriptional Program in NGN2+ Neurons Enriched for Genetic Risk for Brain-Related Disorders
Ma Y, Bendl J, Hartley B, Fullard J, Abdelaal R, Ho S, Kosoy R, Gochman P, Rapoport J, Hoffman G, Brennand K, Roussos P. Activity-Dependent Transcriptional Program in NGN2+ Neurons Enriched for Genetic Risk for Brain-Related Disorders. Biological Psychiatry 2023, 95: 187-198. PMID: 37454787, PMCID: PMC10787819, DOI: 10.1016/j.biopsych.2023.07.003.Peer-Reviewed Original ResearchConceptsTranscriptional programsBrain-related disordersGlutamatergic neuronsGene coexpression network analysisSignificant heritability enrichmentsEnhancer-promoter interactionsCoexpression network analysisDisease-associated genesExpression of genesLarge-scale geneticMultiomics data integrationChromatin accessibilityEpigenomic changesHeritability enrichmentGenetic regulationRegulatory elementsMultiple genesSequence variationGene expressionAxon guidanceGenetic riskPotassium chloride-induced depolarizationActivity-dependent changesDepolarization-induced changesGenes
2022
The role of altered translation in intellectual disability and epilepsy
Malone TJ, Kaczmarek LK. The role of altered translation in intellectual disability and epilepsy. Progress In Neurobiology 2022, 213: 102267. PMID: 35364140, PMCID: PMC10583652, DOI: 10.1016/j.pneurobio.2022.102267.Peer-Reviewed Original ResearchConceptsIntellectual disabilityNeuronal stimulationLocal synaptic activityActivity-dependent changesActivity-dependent translationOverall excitabilitySynaptic activityEpileptic seizuresSynaptic componentsCellular compositionEpilepsyDisabilityIon channelsCell typesDisordersHigher proportionStimulationSeizuresStimuliWorld populationPopulationExcitabilityOriginal stimulusDiseaseMutations
2016
Activity-Dependent Changes in Gene Expression in Schizophrenia Human-Induced Pluripotent Stem Cell Neurons
Roussos P, Guennewig B, Kaczorowski D, Barry G, Brennand K. Activity-Dependent Changes in Gene Expression in Schizophrenia Human-Induced Pluripotent Stem Cell Neurons. JAMA Psychiatry 2016, 73: 1180-1188. PMID: 27732689, PMCID: PMC5437975, DOI: 10.1001/jamapsychiatry.2016.2575.Peer-Reviewed Original ResearchConceptsGene coexpression analysisActivity-dependent changesGene expressionCandidate genesCoexpression analysisSchizophrenia candidate genesSpecific molecular functionsGenome-wide profilingPluripotent stem cell-derived neuronsGene expression differencesSchizophrenia-associated variantsStem cell-derived neuronsDifferential expression analysisNeuronal activity-dependent changesHuman-induced pluripotent stem cell-derived neuronsCell-derived neuronsHuman-induced pluripotent stem cellsPluripotent stem cell neuronsPluripotent stem cellsCommon molecular pathwaysSchizophrenia risk genesMolecular functionsGene networksEtiopathogenesis of schizophreniaExpression analysis
2010
SynCAM 1 Adhesion Dynamically Regulates Synapse Number and Impacts Plasticity and Learning
Robbins EM, Krupp AJ, de Arce K, Ghosh AK, Fogel AI, Boucard A, Südhof TC, Stein V, Biederer T. SynCAM 1 Adhesion Dynamically Regulates Synapse Number and Impacts Plasticity and Learning. Neuron 2010, 68: 894-906. PMID: 21145003, PMCID: PMC3026433, DOI: 10.1016/j.neuron.2010.11.003.Peer-Reviewed Original ResearchConceptsSynapse numberSynCAM 1Excitatory synapse numberLong-term depressionActivity-dependent changesTransgenic brainsExcitatory synapsesMature synapsesTransgenic miceNeuronal connectivityNeuronal circuitsSynapse developmentSpatial learningAdhesion moleculesNeuronal networksSynapsesAdult networksMiceBrainOverexpressionPlasticityExpressionSynaptogenesisEndocannabinoid Mediated Long-Term Depression at Inhibitory Synapses
Chiu C, Castillo P. Endocannabinoid Mediated Long-Term Depression at Inhibitory Synapses. 2010, 149-166. DOI: 10.1007/978-1-4419-6978-1_11.Peer-Reviewed Original ResearchI-LTDLong-term potentiationSynaptic plasticityActivating presynaptic type 1 cannabinoid receptorsHeterosynaptic form of plasticityType 1 cannabinoid receptorInhibitory synapsesGABAergic synaptic plasticityMetabotropic glutamatergic receptorsExcitatory synaptic plasticityBasis of learningECB mobilizationFunction of neural circuitsCellular basis of learningBrain structuresExcitability of neuronsExcitatory glutamatergic synapsesGlutamatergic receptorsExcitatory/inhibitory balanceGABA releaseRetrograde messengerActivity-dependent changesNeural circuitsGABAergic synapsesGlutamatergic synapses
2005
Dissection of synaptic excitability phenotypes by using a dominant-negative Shaker K+ channel subunit
Mosca TJ, Carrillo RA, White BH, Keshishian H. Dissection of synaptic excitability phenotypes by using a dominant-negative Shaker K+ channel subunit. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 3477-3482. PMID: 15728380, PMCID: PMC552910, DOI: 10.1073/pnas.0406164102.Peer-Reviewed Original ResearchConceptsNeuromuscular junctionPostsynaptic membrane excitabilityChannel subunitsActivity-dependent changesPotassium channel subunitsPostsynaptic potentialsNervous system developmentNeuronal excitabilityArbor growthIA currentsPostsynaptic partnersArbor sizeNeurotransmitter releaseMembrane excitabilityLarval neuromuscular junctionElectrical excitabilityExcitabilityElectrical activityBehavioral phenotypesMuscleSh mutationsMorphological changesPhenotypeMotoneuronsNeurons
1983
The supernormal period of the cerebellar parallel fibers effects of [Ca2+]o and [K+]o
Malenka R, Kocsis J, Waxman S. The supernormal period of the cerebellar parallel fibers effects of [Ca2+]o and [K+]o. Pflügers Archiv - European Journal Of Physiology 1983, 397: 176-183. PMID: 6878005, DOI: 10.1007/bf00584354.Peer-Reviewed Original ResearchConceptsSupernormal periodConditioning stimulationActivity-dependent changesParallel fibersCerebellar parallel fibersConditioning volleyIon-sensitive microelectrodesConditioning stimulusExtracellular calciumLatency changesLatency shiftCortex exhibitExtracellular ionic concentrationsTest response latenciesTest latencyStimulationResponse latencyRelative increaseSmall increaseLatencyPeriodSuperfusateExcitability
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