A semi-empirical Bayes approach for calibrating weak instrumental bias in sex-specific Mendelian randomization studies
Huang Y, Kurniansyah N, Levey D, Gelernter J, Huffman J, Cho K, Wilson P, Gottlieb D, Rice K, Sofer T. A semi-empirical Bayes approach for calibrating weak instrumental bias in sex-specific Mendelian randomization studies. American Journal Of Human Genetics 2025, 112: 2213-2231. PMID: 40912238, PMCID: PMC12416758, DOI: 10.1016/j.ajhg.2025.07.015.Peer-Reviewed Original ResearchConceptsWeak instrument biasCVD-related outcomesMillion Veteran ProgramGenome-wide association studiesMendelian randomizationShrinkage estimatorsCausal effectsGenome-wide association study dataMendelian randomization studiesEffect estimatesBayes approachVariable selectionSimulation studyMR analysisInstrumental biasesSex groupsCardiovascular diseaseLong sleep durationBayesian frameworkSleep phenotypesVeteran ProgramEstimationIntervention studiesAssociation studiesSleep duration
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