2024
Urinary biomonitoring of glyphosate exposure among male farmers and nonfarmers in the Biomarkers of Exposure and Effect in Agriculture (BEEA) study
Chang V, Ospina M, Xie S, Andreotti G, Parks C, Liu D, Madrigal J, Ward M, Rothman N, Silverman D, Sandler D, Friesen M, Freeman L, Calafat A, Hofmann J. Urinary biomonitoring of glyphosate exposure among male farmers and nonfarmers in the Biomarkers of Exposure and Effect in Agriculture (BEEA) study. Environment International 2024, 187: 108644. PMID: 38636272, PMCID: PMC12406715, DOI: 10.1016/j.envint.2024.108644.Peer-Reviewed Original ResearchConceptsUrinary glyphosate concentrationsBiomarkers of exposure and effectGlyphosate concentrationsExposure and effectGlyphosate usePesticide exposureGeometric mean concentrationsBiomonitoring dataMean concentrationsUrinary biomonitoringGlyphosate exposureAgricultural settingsGlyphosateSelf-reported pesticide exposureExposed farmersExposure determinantsIsotope-dilution tandem mass spectrometryConcentrationMorning voided urineAgricultureTandem mass spectrometryBiomonitoringExposureFarmsVoided urine
2017
UroMark—a urinary biomarker assay for the detection of bladder cancer
Feber A, Dhami P, Dong L, de Winter P, Tan W, Martínez-Fernández M, Paul D, Hynes-Allen A, Rezaee S, Gurung P, Rodney S, Mehmood A, Villacampa F, de la Rosa F, Jameson C, Cheng K, Zeegers M, Bryan R, James N, Paramio J, Freeman A, Beck S, Kelly J. UroMark—a urinary biomarker assay for the detection of bladder cancer. Clinical Epigenetics 2017, 9: 8. PMID: 28163793, PMCID: PMC5282868, DOI: 10.1186/s13148-016-0303-5.Peer-Reviewed Original ResearchConceptsDetection of bladder cancerEpigenetic alterationsSequencing assayNovel high-throughputBladder cancerBackgroundBladder cancerNext-generation sequencing assayUrinary biomarkersDNA methylationMuscle-invasive bladder cancerUrinary biomarker assaysSediment DNAAnalysis pipelineVoided urine samplesDetection of BCPrimary BCHigh-throughputCystoscopic examinationVoided urineDNAIndependent cohortAssayBiomarker panelDiagnosed BCCancer
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