2017
Identification of tumor-autonomous and indirect effects of vitamin D action that inhibit breast cancer growth and tumor progression
Aggarwal A, Feldman D, Feldman B. Identification of tumor-autonomous and indirect effects of vitamin D action that inhibit breast cancer growth and tumor progression. The Journal Of Steroid Biochemistry And Molecular Biology 2017, 177: 155-158. PMID: 28710021, PMCID: PMC5764828, DOI: 10.1016/j.jsbmb.2017.07.003.Peer-Reviewed Original ResearchConceptsVitamin D deficiencyBreast cancerD deficiencyPoor outcomeInhibit breast cancer growthAssociated with worse prognosisLow vitamin D levelsAggressive molecular phenotypePrimary tumor growthSerum 25(OH)D concentrationsDevelopment of metastasesVitamin D levelsBreast cancer growthBreast cancer patientsHuman breast cancerVitamin D signalingVitamin D receptorBreast cancer cellsVitamin D actionPrimary tumorWorse prognosisD levelsTumor progressionTumor growthD receptor
2009
Chemoprevention of Colorectal Neoplasia by Estrogen: Potential Role of Vitamin D Activity
Protiva P, Cross HS, Hopkins ME, Kállay E, Bises G, Dreyhaupt E, Augenlicht L, Lipkin M, Lesser M, Livote E, Holt PR. Chemoprevention of Colorectal Neoplasia by Estrogen: Potential Role of Vitamin D Activity. Cancer Prevention Research 2009, 2: 43-51. PMID: 19139017, DOI: 10.1158/1940-6207.capr-08-0103.Peer-Reviewed Original ResearchMeSH Keywords25-Hydroxyvitamin D3 1-alpha-HydroxylaseChemopreventionColorectal NeoplasmsEstradiolEstrogen Replacement TherapyEstrogensFemaleGene ExpressionGene Expression ProfilingHumansMiddle AgedReceptors, CalcitriolReverse Transcriptase Polymerase Chain ReactionSteroid HydroxylasesVitamin DVitamin D3 24-HydroxylaseConceptsHormone replacement therapyVitamin D activityReplacement therapyPostmenopausal hormone replacement therapyVitamin D receptor pathwayPrimary end pointRectal mucosal biopsiesVitamin D actionExpression of VDRColon cancer incidenceE-cadherinRegulation of VDREstrogen interventionEstrogen-responsive genesPostmenopausal womenPremenopausal levelsVDR pathwayMucosal biopsiesRectal biopsySerum estradiolVitamin DColorectal neoplasiaD activityRectal mucosaCancer incidence
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