2013
Kinesin 5B (KIF5B) Is Required for Progression through Female Meiosis and Proper Chromosomal Segregation in Mitotic Cells
Kidane D, Sakkas D, Nottoli T, McGrath J, Sweasy JB. Kinesin 5B (KIF5B) Is Required for Progression through Female Meiosis and Proper Chromosomal Segregation in Mitotic Cells. PLOS ONE 2013, 8: e58585. PMID: 23560038, PMCID: PMC3613343, DOI: 10.1371/journal.pone.0058585.Peer-Reviewed Original ResearchConceptsMitotic cell divisionCell divisionKinesin 5BChromosomal segregationMitotic cellsCell developmentGerminal vesicle breakdownKnockdown of KIF5BProper chromosomal segregationChromosomal segregation defectsFemale meiosisSegregation defectsChromosomal stabilityRNA interferenceChromosomal instabilityFirst polar bodyMouse oocytesKIF5BMolecular motorsPolar bodyVesicle breakdownBirth defectsDivisionCellsMeiosis
1998
Effects of ovarian source, patient age, and menstrual cycle phase on in vitro maturation of immature human oocytes
Whitacre K, Seifer D, Friedman C, Coskun S, Kennard E, Kim M, Alak B. Effects of ovarian source, patient age, and menstrual cycle phase on in vitro maturation of immature human oocytes. Fertility And Sterility 1998, 70: 1015-1021. PMID: 9848288, DOI: 10.1016/s0015-0282(98)00339-2.Peer-Reviewed Original ResearchConceptsGerminal vesicle breakdownOvarian sourceNuclear maturationPatient ageGynecologic surgeryFollicular phaseLuteal phaseImmature human oocytesFinal meiotic maturationMenstrual cycle phaseYears of agePercentage of oocytesCycle phaseMetaphase II stageIVF programMenstrual cyclePatient criteriaMAIN OUTCOMEVitro maturationPatientsHuman oocytesOocyte maturationMII stageOocyte's abilityVesicle breakdownActivin a stimulates meiotic maturation of human oocytes and modulates granulosa cell steroidogenesis in vitro
Alak B, Coskun S, Friedman C, Kennard E, Kim M, Seifer D. Activin a stimulates meiotic maturation of human oocytes and modulates granulosa cell steroidogenesis in vitro. Fertility And Sterility 1998, 70: 1126-1130. PMID: 9848305, DOI: 10.1016/s0015-0282(98)00386-0.Peer-Reviewed Original ResearchConceptsGranulosa cell steroidogenesisGerminal vesicle breakdownGranulosa cellsActivin AE2 secretionSteroid secretionCell steroidogenesisNonluteinized granulosa cellsMeiotic maturationMetaphase IIUniversity Medical CenterAntral granulosa cellsNonovarian pathologyInhibin AMedical CenterMAIN OUTCOMEActivin A.Oocyte meiotic maturationImmature oocytesHuman oocytesOocyte maturationSecretionVesicle breakdownProgesteroneSteroidogenesis
1983
Regulation of mouse oocyte meiotic maturation: Implication of a decrease in oocyte cAMP and protein dephosphorylation in commitment to resume meiosis
Schultz R, Montgomery R, Belanoff J. Regulation of mouse oocyte meiotic maturation: Implication of a decrease in oocyte cAMP and protein dephosphorylation in commitment to resume meiosis. Developmental Biology 1983, 97: 264-273. PMID: 6189752, DOI: 10.1016/0012-1606(83)90085-4.Peer-Reviewed Original ResearchConceptsGerminal vesicle breakdownOocyte cAMPResumption of meiosisOocyte cAMP concentrationMeiotic maturationCumulus cell-oocyte complexesLevels of cAMPCAMP phosphodiesterase inhibitorDbcAMP-containing mediumAntral folliclesPreovulatory antral folliclesPhosphodiesterase inhibitorOocyte meiotic maturationCumulus cellsMouse oocyte meiotic maturationCAMP levelsVesicle breakdownCAMP concentrationDibutyryl cAMPBiochemical changesIBMXPeriod of timePossible roleFolliclesOocytes
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