1998
Reduced brain serotonin transporter availability in major depression as measured by [123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane and single photon emission computed tomography
Malison R, Price L, Berman R, van Dyck C, Pelton G, Carpenter L, Sanacora G, Owens M, Nemeroff C, Rajeevan N, Baldwin R, Seibyl J, Innis R, Charney D. Reduced brain serotonin transporter availability in major depression as measured by [123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane and single photon emission computed tomography. Biological Psychiatry 1998, 44: 1090-1098. PMID: 9836013, DOI: 10.1016/s0006-3223(98)00272-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntidepressive AgentsBrainBrain StemCarrier ProteinsCocaineDepressive DisorderFemaleHumansMaleMembrane GlycoproteinsMembrane Transport ProteinsMiddle AgedNerve Tissue ProteinsParoxetinePsychiatric Status Rating ScalesSerotoninSerotonin Plasma Membrane Transport ProteinsTomography, Emission-Computed, Single-PhotonConceptsDepressed patientsMajor depressionHealthy subjectsBrain serotonin transporter availabilitySerotonin transporterBeta-CIT SPECTDensity of brainPost-mortem brain tissuePathophysiology of depressionSerotonin transporter availabilityUnipolar major depressionBeta-CIT bindingSingle photon emissionSerotonergic neuronsBrain uptakeSERT availabilityTransporter availabilityBeta-CITBrain tissueCarbomethoxy-3βPatientsBlood plateletsDepressionPhoton emissionSignificant reduction
1989
Zwitterionic and Anionic Forms of a Serotonin Analog as Transport Substrates
Rudnick G, Kirk K, Fishkes H, Schuldiner S. Zwitterionic and Anionic Forms of a Serotonin Analog as Transport Substrates. Journal Of Biological Chemistry 1989, 264: 14865-14868. PMID: 2549040, DOI: 10.1016/s0021-9258(18)63781-0.Peer-Reviewed Original ResearchConceptsBiogenic amine transportersAmine transportersPlasma membrane serotonin transporterSubstrate translocationBovine chromaffin granulesTransport substratesHuman blood plateletsSerotonin transportChromaffin granulesTransportersBlood plateletsSerotonin transporterKmIdentical ratesTranslocationSubstrateTransport
1979
Mechanism of imipramine inhibition of platelet 5-hydroxytryptamine transport.
Talvenheimo J, Nelson P, Rudnick G. Mechanism of imipramine inhibition of platelet 5-hydroxytryptamine transport. Journal Of Biological Chemistry 1979, 254: 4631-4635. PMID: 438209, DOI: 10.1016/s0021-9258(17)30057-1.Peer-Reviewed Original Research
1978
Platelet 5-hydroxytryptamine transport, an electroneutral mechanism coupled to potassium.
Rudnick G, Nelson P. Platelet 5-hydroxytryptamine transport, an electroneutral mechanism coupled to potassium. Biochemistry 1978, 17: 4739-42. PMID: 728383, DOI: 10.1021/bi00615a021.Peer-Reviewed Original ResearchConceptsPlasma membrane vesiclesLipophilic cation triphenylmethylphosphoniumMembrane potentialMembrane vesiclesElectroneutral mechanismVesicle membraneIon effluxPorcine blood plateletsAbsence of valinomycinAddition of valinomycinPotassium gradientBlood plateletsValinomycinElectrogenic mechanismMembraneNet influxMechanismDinitrophenolVesiclesTransportLittle effectInfluxTriphenylmethylphosphoniumAbsenceEfflux
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