2022
A Neuroimaging Signature of Cognitive Aging from Whole‐Brain Functional Connectivity
Jiang R, Scheinost D, Zuo N, Wu J, Qi S, Liang Q, Zhi D, Luo N, Chung Y, Liu S, Xu Y, Sui J, Calhoun V. A Neuroimaging Signature of Cognitive Aging from Whole‐Brain Functional Connectivity. Advanced Science 2022, 9: 2201621. PMID: 35811304, PMCID: PMC9403648, DOI: 10.1002/advs.202201621.Peer-Reviewed Original ResearchConceptsCognitive declineNormal agingFunctional connectivitySimilar neural correlatesWhole-brain functional connectivityDorsal attention networkBrain network organizationNeural dedifferentiationFluid intelligenceCognitive agingCognitive abilitiesNeural correlatesAttention networkCognitive functionNetwork organizationHuman ageNeuroimaging signaturesCognitionUnique patternAgingConnectivityIntelligenceCorrelatesConstructsHealthy cohortGenome-wide perturbations of Alu expression and Alu-associated post-transcriptional regulations distinguish oligodendroglioma from other gliomas
Hwang T, Kim S, Chowdhury T, Yu H, Kim K, Kang H, Won J, Park S, Shin J, Park C. Genome-wide perturbations of Alu expression and Alu-associated post-transcriptional regulations distinguish oligodendroglioma from other gliomas. Communications Biology 2022, 5: 62. PMID: 35042936, PMCID: PMC8766575, DOI: 10.1038/s42003-022-03011-w.Peer-Reviewed Original ResearchConceptsCircular RNA levelsI editingGenome-wide perturbationsPost-transcriptional processesPost-transcriptional regulationRNA expressionRNA levelsAlu expressionHuman genomeRNA-seqRegulatory elementsRepeat elementsGenetic elementsAlu subfamiliesBiological processesGrade 2 oligodendrogliomaAluExpressionGliomagenesisEditingUnique patternTranscriptomeGenomeSubfamiliesNormal tissues
2018
Tumor-specific MHC-II expression drives a unique pattern of resistance to immunotherapy via LAG-3/FCRL6 engagement
Johnson DB, Nixon MJ, Wang Y, Wang DY, Castellanos E, Estrada MV, Ericsson-Gonzalez PI, Cote CH, Salgado R, Sanchez V, Dean PT, Opalenik SR, Schreeder DM, Rimm DL, Kim JY, Bordeaux J, Loi S, Horn L, Sanders ME, Ferrell PB, Xu Y, Sosman JA, Davis RS, Balko JM. Tumor-specific MHC-II expression drives a unique pattern of resistance to immunotherapy via LAG-3/FCRL6 engagement. JCI Insight 2018, 3: e120360. PMID: 30568030, PMCID: PMC6338319, DOI: 10.1172/jci.insight.120360.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAnimalsAntibodies, NeutralizingAntigens, CDBreast NeoplasmsCD4-Positive T-LymphocytesCell Line, TumorHistocompatibility Antigens Class IIHLA-DR AntigensHumansImmunotherapyKiller Cells, NaturalLigandsLymphocyte Activation Gene 3 ProteinMiceProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-CellReceptors, Cell SurfaceT-LymphocytesTumor MicroenvironmentConceptsMHC-II expressionT cellsAnti-PD-1 therapyTumor cellsPD-1 pathwayTumor-intrinsic factorsPD-1-targeted immunotherapiesMHC-II receptorsDurable responsesPD-1Immune activationImmunotherapy targetPreclinical modelsLAG-3TumorsUnique patternMHCEnhanced expressionInhibitory functionAdaptive resistanceNovel inhibitory functionImmunotherapyPatientsContext-dependent mechanismsCellsPreconfigured patterns are the primary driver of offline multi‐neuronal sequence replay
Liu K, Sibille J, Dragoi G. Preconfigured patterns are the primary driver of offline multi‐neuronal sequence replay. Hippocampus 2018, 29: 275-283. PMID: 30260526, PMCID: PMC6793999, DOI: 10.1002/hipo.23034.Peer-Reviewed Original Research
2015
Functional connectome fingerprinting: identifying individuals using patterns of brain connectivity
Finn ES, Shen X, Scheinost D, Rosenberg MD, Huang J, Chun MM, Papademetris X, Constable RT. Functional connectome fingerprinting: identifying individuals using patterns of brain connectivity. Nature Neuroscience 2015, 18: 1664-1671. PMID: 26457551, PMCID: PMC5008686, DOI: 10.1038/nn.4135.Peer-Reviewed Original ResearchNeuropathology of Traumatic Brain Injury: Comparison of Penetrating, Nonpenetrating Direct Impact and Explosive Blast Etiologies
de Lanerolle NC, Kim JH, Bandak FA. Neuropathology of Traumatic Brain Injury: Comparison of Penetrating, Nonpenetrating Direct Impact and Explosive Blast Etiologies. Seminars In Neurology 2015, 35: 012-019. PMID: 25714863, DOI: 10.1055/s-0035-1544240.Peer-Reviewed Original ResearchConceptsClosed head injuryTraumatic brain injuryDiffuse axonal injuryAxonal injuryMild TBIHead injuryBrain injurySevere closed head injuryModerate traumatic brain injuryModerate closed head injuryMild traumatic brain injuryAnimal TBI modelsMicroglial activationNeuronal injuryTBI modelCerebral vasculatureInjuryNeuropathologyGross disruptionHuman brainBlunt impactUnique patternHumansActivationAstrocytes
2001
Application of Amplified Fragment Length Polymorphism Analysis to Subtyping of Legionella pneumophila Serogroup 6
Benson R, Fields B, Benin A, Craddock H, Besser R. Application of Amplified Fragment Length Polymorphism Analysis to Subtyping of Legionella pneumophila Serogroup 6. 2001, 243-247. DOI: 10.1128/9781555817985.ch45.Peer-Reviewed Original ResearchLegionella pneumophila serogroup 6Serogroup 6Patient isolatesFragment length polymorphism analysisLength polymorphism analysisL. pneumophila serogroup 6Unrelated strainsOutbreak-related strainsPulsed-field gel electrophoresisEnvironmental isolatesPolymorphism analysisEnvironmental strainsOutbreak investigationWhirlpool spaLegionnaires' diseasePontiac feverUnique strainsElectrophoretic typesDiseaseIsolatesGel electrophoresisSubtypingUnique patternAgarose gel electrophoresis
2000
The predator odor, TMT, displays a unique, stress-like pattern of dopaminergic and endocrinological activation in the rat
Morrow B, Redmond A, Roth R, Elsworth J. The predator odor, TMT, displays a unique, stress-like pattern of dopaminergic and endocrinological activation in the rat. Brain Research 2000, 864: 146-151. PMID: 10793199, DOI: 10.1016/s0006-8993(00)02174-0.Peer-Reviewed Original ResearchConceptsDopamine metabolismSerum corticosteroneAcute exposureCentral dopamine metabolismNucleus accumbens coreMedial prefrontal cortexFear-inducing behaviorPredator odorCentral effectsAccumbens coreRatsStressful stimuliPrefrontal cortexConditioned fearAltered behaviorControl odorAversive stimuliCorticosteroneMetabolismOpen fieldBiochemical activationUnique patternExposureActivationTMT
1994
Evidence from two genetic syndromes for a dissociation between verbal and visual-spatial short-term memory
Wang P, Bellugi U. Evidence from two genetic syndromes for a dissociation between verbal and visual-spatial short-term memory. Journal Of Clinical And Experimental Neuropsychology 1994, 16: 317-322. PMID: 8021317, DOI: 10.1080/01688639408402641.Peer-Reviewed Original ResearchConceptsShort-term memory taskMemory taskVerbal short-term memory taskVisual-spatial short-term memoryPatterns of brain morphologyVisual-spatial stimuliDown syndromeNeuropsychological profileDouble dissociationShort-term memoryWilliams syndromeNeurogenetic evidenceAbility of subjectsBrain morphologyAbnormal neurodevelopmentShort-term storageGenetic syndromesTaskUnique patternVerbalMemoryStimuliNeurodevelopmentSubjectsEvidence
1990
Neonatal Excitotoxic Brain Injury
Young R, Petroff O, Novotny E, Wong M. Neonatal Excitotoxic Brain Injury. Developmental Neuroscience 1990, 12: 210-220. PMID: 2142073, DOI: 10.1159/000111850.Peer-Reviewed Original ResearchConceptsQuisqualic acidBrain injuryNeonatal excitotoxic brain injuryExcitotoxic brain injuryHypoxic-ischemic injuryNeonatal rat brainN-acetyl aspartateExcitotoxic damageNeuronal necrosisNeuropathologic examinationParoxysmal dischargesNeonatal ratsElectroencephalographic monitoringHilar areaRat brainMedial CA1Pathologic alterationsMetabolic alterationsParahippocampal regionPathological effectsGlutamate analogueInjuryPhysiologicUnique patternAlterations
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