2014
A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain
Gui J, Liu B, Cao G, Lipchik AM, Perez M, Dekan Z, Mobli M, Daly NL, Alewood PF, Parker LL, King GF, Zhou Y, Jordt SE, Nitabach MN. A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain. Current Biology 2014, 24: 473-483. PMID: 24530065, PMCID: PMC3949122, DOI: 10.1016/j.cub.2014.01.013.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBinding SitesDrug Evaluation, PreclinicalFemaleGene LibraryHumansMolecular Sequence DataNAV1.2 Voltage-Gated Sodium ChannelOocytesPeptidesProtein Structure, TertiarySpider VenomsTransient Receptor Potential ChannelsVoltage-Gated Sodium Channel BlockersXenopus ProteinsConceptsTransient receptor potential ankyrin 1Ion channel modifiersProTxIon channel transient receptor potential ankyrin 1Channel modifiersPeptide toxinsSpecific peptidesIon channelsVoltage-gated sodium channelsContext of painS1-S4Spider venomPotential clinical applicationsTRPA1 antagonistTRPA1 functionAnkyrin 1PeptidesModifiersPeptide antagonistAntagonistSodium channelsPharmacological reagentsReagentsClinical applicationNav1.2
1982
Synaptic vesicle recycling at the neuromuscular junction in the presence of a presynaptic membrane marker
Lentz T, Chester J. Synaptic vesicle recycling at the neuromuscular junction in the presence of a presynaptic membrane marker. Neuroscience 1982, 7: 9-20. PMID: 6176905, DOI: 10.1016/0306-4522(82)90148-8.Peer-Reviewed Original ResearchConceptsSynaptic vesicle recyclingSynaptic vesiclesVesicle recyclingNew synaptic vesiclesAxolemmal infoldingsPresynaptic axonal membraneMechanism of recyclingSynaptic vesicle releaseNeuromuscular junctionBlack widow spider venomMembranous cisternaeVesicle membraneCoated vesiclesVesicle releaseSpider venomAxonal membraneMembrane markersVesiclesMembraneExternal potassium ionsCisternaeInfoldingsRecyclingMarkersBungarotoxin
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