2024
Macrophages restrain pathological interferon responses during viral respiratory infection
Rodriguez-Morales P, Hoagland D, Mann A, Yu S, Lai A, Baez Vazquez A, Medzhitov R, Franklin R. Macrophages restrain pathological interferon responses during viral respiratory infection. The Journal Of Immunology 2024, 212: 0536_5144-0536_5144. DOI: 10.4049/jimmunol.212.supp.0536.5144.Peer-Reviewed Original ResearchIFN-I productionOncostatin MBlockade of IFN-I signalingViral stimuliEpithelial cellsIFN-IOSM-deficient miceViral respiratory infectionsTriggered by infectionInflammation-induced pathologyLung epithelial cellsIFN-I responseIFN-I signalingRegulation of inflammationType I interferonPoly(I:CAcute blockadeCytokine oncostatin MRespiratory infectionsUncontrolled inflammationInflammatory responseI interferonInterferon responseRespiratory tractMice
2023
Postinfectious Inflammation, Autoimmunity, and Obsessive-Compulsive Disorder: Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection, and Pediatric Acute-Onset Neuropsychiatric Disorder
Vreeland A, Calaprice D, Or-Geva N, Frye R, Agalliu D, Lachman H, Pittenger C, Pallanti S, Williams K, Ma M, Thienemann M, Gagliano A, Mellins E, Frankovich J. Postinfectious Inflammation, Autoimmunity, and Obsessive-Compulsive Disorder: Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection, and Pediatric Acute-Onset Neuropsychiatric Disorder. Developmental Neuroscience 2023, 45: 361-374. PMID: 37742615, DOI: 10.1159/000534261.Peer-Reviewed Original ResearchConceptsPediatric acute-onset neuropsychiatric syndromeObsessive-compulsive disorderGroup A streptococciSydenham's choreaNeuropsychiatric disordersStreptococcal infectionAcute-onset obsessive-compulsive disorderPediatric autoimmune neuropsychiatric disorders associated with streptococcal infectionsAssociated with streptococcal infectionsAnimal modelsPediatric autoimmune neuropsychiatric disordersAnti-neuronal autoantibodiesAutoimmune neuropsychiatric disordersTriggered by infectionModulate neuronal activityRandomized clinical trialsNeuropsychiatric syndromeNeuropsychiatric manifestationsRheumatologic diseasesClinical trialsA streptococciNeural antigensBasal gangliaClinical syndromeNeuronal activity
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